development of hepatocellular carcinoma novel therapeutics that target wnt signaling and dUTPase
| Project/Area Number |
24701024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | dUTPase / EpCAM / β-catenin / Wnt / HCC / β-HIVS / wnt / Synthetic Lethality |
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| Research Abstract |
Examples of drugs having dUTPase inhibitory effect was identified as a component of the Chinese herb Lithospermum a beta-HIVS. Create a similar compound of HIVS, it was confirmed liver cancer cell growth inhibitory effect. I have revealed a positive correlation of expression of dUTPase and EpCAM. In suppression of the expression of beta-catenin, the observed decrease in activity dUTpase promoter, expression of dUTPase found the possibility of being regulated in Wnt signaling, a strong expression of dUTPase activation of Wnt signaling.
The apparent correlation of EpCAM and Wnt / beta-catenin signaling and dUTPase, dUTPase as inhibitors, were identified, create a beta-HIVS similar compounds.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling.2013
Author(s)
Ueda T, Honda M, Horimoto K, Aburatani S, Saito S, Yamashita T, Sakai Y, Nakamura M, Takatori H, Sunagozaka H, Kaneko S.
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Journal Title
Genomics.
Volume: Apr;101(4)
Issue: 4
Pages: 238-48
DOI
Related Report
Peer Reviewed
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