| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
We identified key microRNAs in recurrent cases of hepatocellular carcinoma after living donor liver transplantation.
MiR-18a expression was increased, and miR-199a-5p expression was decreased in HCC and metastasis. High levels of miR-18a expression correlated with high levels of tumor markers, larger tumor size, and a high recurrence rate. Lower miR-199a-5p expression levels correlated with high levels of tumor marker levels, portal venous invasion, and a high recurrence rate. In HCC cells, miR-18a regulated the expression of tumor necrosis factor alpha induced protein 3 (TNFAIP3), and miR-199a-5p regulated the expression of hypoxia-inducible factor 1 alpha (HIF1A), vascular endothelial growth factor A (VEGFA), insulin-like growth factor 1 receptor (IGF1R), and insulin-like growth factor 2 (IGF2).
Increased miR-18a levels and decreased miR-199a-5p levels are involved in progression and poor prognosis of HCC and affect the expression of multiple genes.
|
