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Identificationof novel diagnostic and therapeutic factors for endocrine therapy-resistant breast cancer by next-generation sequencing strategy

Research Project

Project/Area Number 24701033
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Clinical oncology
Research InstitutionKagoshima University

Principal Investigator

IJICHI Nobuhiro  鹿児島大学, 大学院・医歯学総合研究科, 助教 (80380624)

Project Period (FY) 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords内分泌療法 / 乳がん / エストロゲン / FOXP1 / 次世代シーケンサー / FOXA1 / Erα / タモキシフェン耐性
Research Abstract

To identify the novel diagnostic and therapeutic factors for endocrine therapy-resistant breast cancer, we focused on FOXP1, one of a forkhead transcription factor family, as a candidate, and its genome-wide distributionin ERα-positive breast cancer MCF-7 cells was examined by next-generation sequencing strategy. We demonstrated that majority of binding regions of FOXP1 in MCF-7 cells stimulated with estrogen were overlapped with those of both Erαand FOXA1. We also demonstrated that the double-positive immunoreactivities of FOXP1 and FOXA1 are significantly associated with a favorable prognosis for survival of breast cancer patients receiving adjuvant tamoxifen therapy. In this study, we revealed that, similar to FOXA1, FOXP1 is assumed to be a critical transcription factor for Erαsignaling, and both forkhead transcription factors can serve as predictive factors for acquired endocrine resistance in breast cancer.

Report

(2 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (7 results)

All 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Association of double-positive FOXA1 and FOXP1 immunoreactivities with favorable prognosis of tamoxifen-treated breast cancer patients2012

    • Author(s)
      Ijichi N, Shigekawa T, Ikeda K,Horie-Inoue K, Shimizu C, Saji S, Aogi K, Tsuda H, Osaki A, Saeki T, Inoue S
    • Journal Title

      Horm Cancer

      Volume: 3 Issue: 4 Pages: 147-159

    • DOI

      10.1007/s12672-012-0111-0

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Forkhead box transcription factor, forkhead box A1, shows negative association with lymph node status in endometrial cancer, and represses cell proliferation and migration of endometrial cancer cells2012

    • Author(s)
      Abe Y, Ijichi N, Ikeda K, Kayano H, Horie-Inoue K, Takeda S, Inoue S
    • Journal Title

      Cancer Sci

      Volume: 103 Issue: 4 Pages: 806-812

    • DOI

      10.1111/j.1349-7006.2012.02201.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] フォークヘッド転写因子FOXP1 の全ゲノムにおける結合部位同定による ER シグナル調節機構の解析2012

    • Author(s)
      伊地知暢広、堀江公仁子、池田和博、大石貴史、井上聡
    • Organizer
      第20回日本ステロイドホルモン学会
    • Place of Presentation
      石川
    • Year and Date
      2012-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] EBAG9 immunoreactivity is a potential prognostic factor for poor outcome of breast cancer patients with adjuvant tamoxifen therapy2012

    • Author(s)
      Shigekawa T, Ijichi N, Ikeda K, Miyazaki T, Horie-Inoue K, Shimizu C, Saji S, Aogi K, Tsuda H, Osaki A, Saeki T, Inoue S
    • Organizer
      35th San Antonio Breast Cancer Symposium, San Antonio
    • Place of Presentation
      Texas, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] ホルモン療法抵抗性前立腺がん細胞におけるエネルギー代謝関連核内受容体作用の検討2012

    • Author(s)
      堀江公仁子、高山賢一、伊地知暢広、池田和博、井上聡
    • Organizer
      脳心血管抗加齢研究会2012
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] フォークヘッド転写因子FOXP1の全ゲノムにおける結合部位同定によるERシグナル調節機構の解析2012

    • Author(s)
      伊地知 暢広
    • Organizer
      第20回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2012 Annual Research Report
  • [Book] HORMONES AND BREAST CANCER, Elsevier

    • Author(s)
      Ijichi N, Ikeda K, Horie-Inoue K, Inoue S
    • Publisher
      (in press)
    • Related Report
      2012 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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