Prognostic model of cancer patients using the relative survival regression tree

• Project/Area Number: 24701042
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cancer epidemiology and prevention
• Research Institution: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
• Principal Investigator: YURI Ito 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他 (60585305)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 生存解析 / がん登録 / 予後予測モデル / がん / 生存率 / 樹木構造接近法

Outline of Final Research Achievements

We developed the regression tree based on the relative survival approach. Using this data mining approach, we can explore the prognostic factors and classify patients to significant subgroups from database with many candidate variables. We applied to the data of non-small-cell lung cancer patients from the hospital cancer registry data of our institute linking with the lifestyle survey for patients. Stage at diagnosis was the most important prognostic factor. Smoking status was a prognostic factor among the localised patients. We proposed that this approach can classified patients to subgroups with different prognosis.

Research Products

• [Journal Article] Anatomical versus non-anatomical resection for hepatocellular carcinoma (2015)
  • Author(s): Marubashi S, Gotoh K, Akita H, Takahashi H, Ito Y, Yano M, Ishikawa O, Sakon M.
  • Journal Title: Br J Surg Volume: 102 Issue: 7 Pages: 776-84
  • DOI: 10.1002/bjs.9815
  • Peer Reviewed
• [Journal Article] Advance and stagnation in the treatment of patients with lymphoma and myeloma: Analysis using population-based cancer registry data in Japan from 1993 to 2006 (2015)
  • Author(s): Chihara D, Ito H, Izutsu K, Hattori M, Nishino Y, Ioka A, Matsuda T, Ito Y.
  • Journal Title: Int J Cancer Volume: - Issue: 5 Pages: 1217-1223
  • DOI: 10.1002/ijc.29477
  • Peer Reviewed
• [Journal Article] Determinants of participation in prostate cancer screening: A simple analytical framework to account for healthy-user bias. (2015)
  • Author(s): Tabuchi T, Nakayama T, Fukushima W, Matsunaga I, Ohfuji S, Kondo K, Kawano E, Fukuhara H, Ito Y, Oshima A.
  • Journal Title: Cancer Sci. Volume: - Issue: 1 Pages: 108-114
  • DOI: 10.1111/cas.12561
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of Recurrence Patterns After Anatomical or Non-anatomical Resection for Hepatocellular Carcinoma. (2015)
  • Author(s): Marubashi S, Gotoh K, Akita H, Takahashi H, Sugimura K, Miyoshi N, Motoori M, Kishi K, Noura S, Fujiwara Y, Ohue M, Nakazawa T, Nakanishi K, Ito Y, Yano M, Ishikawa O, Sakon M.
  • Journal Title: Ann Surg Oncol Volume: - Issue: 7 Pages: 2243-2252
  • DOI: 10.1245/s10434-014-4214-4
  • Peer Reviewed
• [Journal Article] Socioeconomic inequalities in cancer survival: A population-based study of adult patients diagnosed in Osaka, Japan, during the period 1993-2004 (2014)
  • Author(s): Ito Y, Nakaya T, Nakayama T, Miyashiro I, Ioka A, Tsukuma H, Rachet B.
  • Journal Title: Acta Oncologica Volume: 53 Issue: 10 Pages: 1423-1433
  • DOI: 10.3109/0284186x.2014.912350
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Long-term survival and conditional survival of cancer patients in Japan using population-based cancer registry data. (2014)
  • Author(s): Ito Y, Miyashiro I, Ito H, Hosono S, Chihara D, Nakata-Yamada K, Nakayama M, Matsuzaka M, Hattori M, Sugiyama H, Oze I, Tanaka R, Nomura E, Nishino Y, Matsuda T, Ioka A, Tsukuma H, Nakayama T, the J-CANSIS Research Group.
  • Journal Title: Cancer Science Volume: 105 Issue: 11 Pages: 1480-6
  • DOI: 10.1111/cas.12525
  • Peer Reviewed / Open Access
• [Journal Article] 大阪府におけるがん患者の生存率の社会経済格差：1993-2004年診断患者による分析 (2014)
  • Author(s): 伊藤ゆり, 中谷友樹, 宮代勲, 井岡亜希子, 中山富雄
  • Journal Title: JACR Monograph Volume: 20 Pages: 69-78
  • Peer Reviewed
• [Journal Article] Steroid treatment increases the recurrence of radiation-induced organizing pneumonia after breast-conserving therapy. (2014)
  • Author(s): Otani K, Nishiyama K, Ito Y, Kawaguchi Y, Inaji H.
  • Journal Title: Cancer Med Volume: 3 Issue: 4 Pages: 947-53
  • DOI: 10.1002/cam4.255
  • Peer Reviewed
• [Journal Article] Complete Workplace Indoor Smoking Ban and Smoking Behavior among Male Workers and Female Non-smoking Workers' husbands: A Pseudo-cohort Study of Japanese Public Workers (2014)
  • Author(s): Takahiro Tabuchi, Takahiro Hoshino, Hitomi Hama, Kayo Nakata (Yamada), Yuri Ito, Akiko Ioka, Akiko Ikeda, Tomio Nakayama, Isao Miyashiro, and Hideaki Tsukuma
  • Journal Title: BioMed Research International Volume: Volume2014 Pages: 9-9
  • DOI: 10.1155/2014/303917
  • Peer Reviewed / Open Access
• [Journal Article] Conditional survival for longer-term survivors from 2000-2004 using population-based cancer registry data in Osaka, Japan (2013)
  • Author(s): Ito Y, Nakayama T, Miyashiro I, Ioka A, Tsukuma H.
  • Journal Title: BMC cancer Volume: 13(1) Issue: 1 Pages: 304-304
  • DOI: 10.1186/1471-2407-13-304
  • Peer Reviewed
• [Journal Article] たばこ税・価格の引き上げによるたばこ販売実績への影響. (2013)
  • Author(s): 伊藤ゆり, 中村正和.
  • Journal Title: 日本公衆衛生学会誌 Volume: 60 Pages: 613-618
  • NAID: 10031201643
  • Peer Reviewed
• [Journal Article] 市町村におけるがん検診精度管理指標の評価方法について -Funnel plotによる評価-. (2013)
  • Author(s): 伊藤ゆり, 中山富雄, 山崎秀男, 津熊秀明.
  • Journal Title: 厚生の指標 Volume: 60 Pages: 20-25
  • NAID: 40019803249
  • Peer Reviewed
• [Journal Article] 大阪府がん対策推進計画の立案・評価における各種がん統計資料の活用. (2013)
  • Author(s): 伊藤ゆり, 中山富雄, 宮代 勲, 田淵貴大, 井岡亜希子, 池田章子, 津熊秀明.
  • Journal Title: JACR Monograph Volume: 19 Pages: 19-28
  • Peer Reviewed
• [Journal Article] Descriptive epidemiology of bile duct carcinoma in Osaka. (2013)
  • Author(s): Ikeda A, Miyashiro I, Nakayama T, Ioka A, Tabuchi T, Ito Y, Tsukuma H.
  • Journal Title: Jpn J Clin Oncol Volume: 43 Issue: 11 Pages: 1150-1155
  • DOI: 10.1093/jjco/hyt126
  • Peer Reviewed
• [Journal Article] Does removal of out-of-pocket costs for cervical and breast cancer screening work? A quasi-experimental study to evaluate the impact on attendance, attendance inequality and average cost per uptake of a Japanese government intervention. (2013)
  • Author(s): Tabuchi T, Nakayama T, et al.
  • Journal Title: Int J Cancer Volume: 133 Issue: 4 Pages: 972-983
  • DOI: 10.1002/ijc.28095
  • Peer Reviewed
• [Journal Article] 第二期大阪府がん対策推進計画におけるがん検診受診率の目標値設定. (2013)
  • Author(s): 伊藤ゆり, 中山富雄, 田淵貴大, 井岡亜希子, 池田章子, 宮代 勲, 津熊秀明.
  • Journal Title: JACR Monograph Volume: 19 Pages: 162-164
• [Journal Article] A Retrospective Study of the Novel Combination of Paclitaxel and S1 for Pretreated Advanced Non-Small Cell Lung Cancer. (2013)
  • Author(s): Aono N, Ito Y, Nishino K, Uchida J, Kumagai T, Akazawa Y, Okuyama T, Yoshinami T, Imamura F
  • Journal Title: Chemotherapy Volume: 58 Issue: 6 Pages: 454-460
  • DOI: 10.1159/000345624
  • Peer Reviewed
• [Journal Article] 子宮頸がん検診の無料クーポン券配布および未受診者への受診再勧奨の効果：コール・リコール制度の試み. (2012)
  • Author(s): 伊藤ゆり, 北尾淑恵, 中山富雄, 渋谷大助
  • Journal Title: 公衆衛生 Volume: 76 Pages: 827-832
  • NAID: 40019456047
  • Peer Reviewed
• [Journal Article] がん患者の治癒率とは？～がんの予後を示す新しい指標～ (2012)
  • Author(s): 伊藤ゆり
  • Journal Title: 成人病 Volume: 52 Pages: 21-22
• [Journal Article] Cancer incidence and mortality in Osaka, Japan: future trends estimation with an age-period-cohort model (2012)
  • Author(s): Utada M, Ohno Y, Shimizu S, Ito Y, Tsukuma H
  • Journal Title: Asian Pacific Journal of Cancer Prevention Volume: 13 Pages: 3893-3898
  • Peer Reviewed
• [Journal Article] Trends in ‘Cure’ Fraction from Colorectal Cancer by Age and Tumour Stage Between 1975 and 2000, Using Population-based Data, Osaka, Japan (2012)
  • Author(s): Ito Y, Nakayama T, Miyashiro I, Sugimoto T, Ioka A, Tsukuma H, Abdel-Rahman ME, Rachet B
  • Journal Title: Jpn J Clin Oncol Volume: 42 Issue: 10 Pages: 974-983
  • DOI: 10.1093/jjco/hys132
  • Peer Reviewed
• [Journal Article] Intralesional steroid injection to prevent stricture after endoscopic submucosal dissection for esophageal cancer: a controlled prospective study. (2012)
  • Author(s): Hanaoka N, Ishihara R, Takeuchi Y, Uedo N, Higashino K, Ohta T, Kanzaki H, Hanafusa M, Nagai K, Matsui F, Iishi H, Tatsuta M, Ito Y.
  • Journal Title: Endoscopy Volume: 44 Issue: 11 Pages: 1007-1011
  • DOI: 10.1055/s-0032-1310107
  • Peer Reviewed
• [Presentation] Trends in long-term survival for cancer patients in Japan using population-based cancer registry data in 1993-2006: the J-CANSIS study (2015)
  • Author(s): Ito Y, Miyashiro I, Ito H, Hosono S, Chihara D, Nakata-Yamada K, Nakayama M, Matsuzaka M, Hattori M, Sugiyama H, Oze I, Tanaka R, Nomura E, Nishino Y, Matsuda T, Ioka A, Tsukuma H, Nakayama T, the J-CANSIS research group.
  • Organizer: 第25回日本疫学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-01-22 – 2015-01-23
• [Presentation] 肺がん生存率の国際比較 (2014)
  • Author(s): 伊藤ゆり
  • Organizer: 第29回肺がん集検セミナー
  • Place of Presentation: 京都
  • Year and Date: 2014-11-16
  • Invited
• [Presentation] Patterns of conditional survival of 23 cancer sites in Japan using population-based cancer registry data (2014)
  • Author(s): Ito Y, Miyashiro I, Ito H, Hosono S, Chihara D, Nakata K, Nakayama M, Hattori M, Oze I, Nishino Y, Matsuda T, Ioka A, Nakayama T.
  • Organizer: The 73rd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] TEMPORAL TRENDS IN THE PROPORTION ‘CURED’: 23 SITES OF CANCER IN JAPAN 1993-2006. (2014)
  • Author(s): Ito Y, Ito H, Matsuda T, Ioka A, Miyashiro I, Nakayama T, Nakata-Yamada K, Hattori M, Nishino Y, Tsukuma H.
  • Organizer: 36th IACR Conference
  • Place of Presentation: Ottawa, Canada
  • Year and Date: 2014-06-26 – 2014-06-28
• [Presentation] Survival of female breast cancer among adolescents and young adults, a population-based study in Osaka, Japan. (2014)
  • Author(s): Nakata-Yamada K, Ioka A, Ikeda A, Tabuchi T, Nakayama T, Ito Y, Miyashiro I, Tsukuma H
  • Organizer: 36th IACR Conference
  • Place of Presentation: Ottawa, Canada
  • Year and Date: 2014-06-26 – 2014-06-28
• [Presentation] 地域がん登録データに対する治癒モデルの適用とその結果の考察 (2014)
  • Author(s): 伊藤ゆり, 杉本知之, 宮代 勲, 中山富雄
  • Organizer: 2014年度日本計量生物学会年会
  • Place of Presentation: 立川
  • Year and Date: 2014-05-23 – 2014-05-24
• [Presentation] 大阪府における大腸がん検診の精検受診勧奨方法と精検受診率の関係：効果的な精検受診勧奨方法は何か？ (2014)
  • Author(s): 伊藤ゆり, 中山富雄, 山崎秀男, 津熊秀明.
  • Organizer: 第24回日本疫学会学術総会.
  • Place of Presentation: 仙台
• [Presentation] Prognostic model of cancer patients using hospital cancer registry: application of the relative survival regression tree. (2013)
  • Author(s): Ito Y, Nakayama T, Miyashiro I, Tsukuma H.
  • Organizer: The 72nd annual meeting of Japanese Cancer Association.
  • Place of Presentation: Yokohama, Japan
• [Presentation] Descriptive epidemiology of prostate cancer in Osaka, Japan: 1975-2010. (2013)
  • Author(s): Ito Y, Nakayama T, Ioka A, Tanaka H, Tsukuma H.
  • Organizer: The 35th annual meeting of International Association of Cancer Registries.
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Socioeconomic inequalities in cancer survival in Osaka, Japan: 1993-2004. (2013)
  • Author(s): Ito Y, Nakaya T, Nakayama T, Ioka A, Tsukuma H, Rachet B.
  • Organizer: The 35th annual meeting of International Association of Cancer Registries.
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Investigating spatial clusters of cancer incidence in Osaka Prefecture, Japan: An application of GIS for Cancer Control. (2013)
  • Author(s): Ito Y, Nakaya T, Ioka A, Nakayama T, Tsukuma H.
  • Organizer: IGU Kyoto Regional Conference.
  • Place of Presentation: Kyoto, Japan
• [Presentation] Multimodality therapy for pancreatic cancer: Outcomes based on the hospital cancer registry of OMCC. (2013)
  • Author(s): Miyashiro I, Ikeda A, Ioka A, Ito Y, Nakata K, Tabuchi T, Nakayama T, Yano M, Tsukuma H
  • Organizer: The 72nd annual meeting of Japanese Cancer Association
  • Place of Presentation: Yokohama, Japan
• [Presentation] 術後補助療法未施行筋層非浸潤性膀胱癌の膀胱内再発に対するリスク因子の検討. (2013)
  • Author(s): 中山雅志, 林裕次郎, 石津谷祐, 武田健, 山口唯一郎, 新井康之, 垣本健一, 伊藤ゆり, 西村和郎.
  • Organizer: 第51回日本癌治療学会学術集会.
  • Place of Presentation: 京都
• [Presentation] 喫煙状況別にみたがん検診(肺・胃・大腸)受診状況 大阪市民の断面調査. (2013)
  • Author(s): 濱秀聡, 田淵貴大, 中山富雄, 福島若葉, 松永一朗, 伊藤ゆり, 宮代勲.
  • Organizer: 第72回日本公衆衛生学会総会.
  • Place of Presentation: 三重
• [Presentation] 日本における医療保険別の喫煙率格差. (2013)
  • Author(s): 田淵貴大, 中山富雄, 伊藤ゆり, 宮代勲.
  • Organizer: 第72回日本公衆衛生学会総会.
  • Place of Presentation: 三重
• [Presentation] がん患者の生存率の社会経済因子による格差：大阪府がん登録資料による検討 (2013)
  • Author(s): 伊藤ゆり, 中谷友樹, 中山富雄, 田淵貴大, 宮代勲, 井岡亜希子, 池田章子, 津熊秀明
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] Trends in ' Cure from Cancer in Osaka, Japan in 1975-2004: 13 Major Sites of Solid Tumour (2012)
  • Author(s): Ito Y, Nakayama T, Miyashiro I, Tsukuma H, Rachet B
  • Organizer: World Cancer Congress, UICC
  • Place of Presentation: Montreal, Canada
• [Presentation] Conditional five-year relative survival for cancer survivors from 2000-2004 in Osaka, Japan, (がんX年サバイバーにおけるその後の5年相対生存率：2000-2004) (2012)
  • Author(s): Ito Y, Nakayama T, Miyashiro I, Tabuchi T, Ioka A, Tsukuma H
  • Organizer: 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 札幌
• [Presentation] 市町村におけるがん検診精度管理指標の評価方法について ―Funnel Plotによる評価― (2012)
  • Author(s): 伊藤ゆり, 濱 秀聡, 池田章子, 中山富雄
  • Organizer: 第71回日本公衆衛生学会総会
  • Place of Presentation: 山口
• [Book] がん統計白書（第3章 がんの罹患と死亡動向の府県別分析） (2012)
  • Author(s): 井岡亜希子, 伊藤ゆり, 津熊秀明
  • Total Pages: 18
  • Publisher: 篠原出版新社
• [Book] がん統計白書（第9章 がん生存率の国際比較） (2012)
  • Author(s): 伊藤ゆり
  • Total Pages: 11
  • Publisher: 篠原出版新社