Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
DNA double-strand breaks (DSBs) are severe DNA damage that can be caused by anti-cancer drug to kill cancer cells. Camptothecin (CPT) causes DSB via DNA replication in growing cells. However, cellular responses to DNA replication-mediated DSB (RM-DSB) had not been revealed. In this study, we analyzed regulatory mechanisms of RM-DSB repair pathway and discovered that UbcH5c, a E2 ubiquitin-conjugating enzyme, is involved in NHEJ pathway of RM-DSB repair leading to chromosomal aberration.
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