Elucidation of tissue-dependent chromosome aberration frequencies induced by ionizing radiation exposure to the fetus
| Project/Area Number |
24710067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Radiation Effects Research Foundation |
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Principal Investigator |
HAMASAKI Kanya 公益財団法人放射線影響研究所, 遺伝学部, 研究員 (80443597)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 放射線 / 胎児期被ばく / 染色体異常 / 甲状腺上皮細胞 / 脾臓Ｔリンパ球 / 造血幹細胞 / 遺伝子発現 / 胎児被ばく |
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| Outline of Final Research Achievements |
The data of fetal biological responses to ionizing radiation are essential for discussing the cancer risks following fetal exposure to radiation. In this study, we examined the chromosome aberration frequency in both thyroid and spleen T lymphocytes of adult mice that X ray-irradiated as fetuses. Our previous and current results indicate that the frequencies of chromosome aberration induced by fetal irradiation vary with the differences of tissues and irradiation period. Thus, it is suggested that the fetal radio-sensitivity is complicated.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Fetal irradiation induces persistent translocations in rat mammary epithelial cells.2014
Author(s)
Nakano, M,, Nishimura, M., Hamasaki, K., Mishima, S., Yoshida. M., Nakata. A., Shimada, Y., Noda, A.
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Journal Title
Radiation Res.
Volume: 181(2)
Issue: 2
Pages: 172-176
DOI
Related Report
Peer Reviewed
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