Novel disruption mechanism of thyroid hormone system via deiodinase activity inhibition by environmental chemicals
| Project/Area Number |
24710071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima International University |
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Principal Investigator |
SHIMIZU Ryo 広島国際大学, 薬学部, 助教 (00570491)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 脱ヨウ素化酵素 / 甲状腺ホルモン / 内分泌撹乱化学物質 / ハロゲン化合物 / 内分泌かく乱化学物質 |
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| Research Abstract |
In this study, we found that halogenated environmental chemicals substituted hydroxyl group and halogen atom on a phenyl ring inhibited iodotyrosine deiodinase (IYD). IYD-inhibitory agents included polychlorinated biphenyls, polybrominated diphenyl ethers, pharmaceuticals, antiparasitics for animal use, agrichemicals and food colorants. These chemicals may disturb thyroid hormone homeostasis via inhibition of IYD activity.
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Report
(3 results)
Research Products
(30 results)
