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Application of carbon nanotubes to oral drug carriers for the treatment of ulcerative colitis

Research Project

Project/Area Number 24710133
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nanomaterials/Nanobioscience
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

NAKAMURA MAKI  国立研究開発法人産業技術総合研究所, ナノ材料研究部門, 研究員 (00568925)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsナノ材料 / ナノホーン / 経口投与 / 潰瘍性大腸炎 / 薬物送達
Outline of Final Research Achievements

Carbon nanotubes (CNTs) are nanometer-sized carbon materials, and are expected to be applicable to drug carriers for selective drug delivery to the diseased part. Our goal is to establish oral drug delivery system that carries drugs selectively to colon by using composites of CNT and drugs for ulcerative colitis. In this study, for the establishment of effective systems, we developed a technique for surface modification of the CNT-drug composites with polymers, and showed the anti-inflammatory effects of the composites by cell experiments.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Gastrointestinal actions of orally-administered single-walled carbon nanohorns2014

    • Author(s)
      中村真紀、田原善夫、村上達也、飯島澄男、湯田坂雅子
    • Journal Title

      Carbon

      Volume: 69巻 Pages: 409-416

    • DOI

      10.1016/j.carbon.2013.12.043

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evidence of selective oxidation in surface layers of graphite-like thin sheets by mild oxidation2014

    • Author(s)
      中村真紀、河合孝純、弓削亮太、坂東俊治、飯島澄男、湯田坂雅子
    • Journal Title

      Carbon

      Volume: 71巻 Pages: 70-75

    • DOI

      10.1016/j.carbon.2014.01.014

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Cytotoxicity of Carbon Nanohorns Enhanced by Too Much PLPEG2015

    • Author(s)
      中村真紀、田原善夫、深田伸介、張民芳、飯島澄男、湯田坂雅子
    • Organizer
      第48回 フラーレン・ナノチューブ・グラフェン総合シンポジウム
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2015-02-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Selective carboxylation of graphite-like thin sheet edges in carbon nanohorn aggregates

    • Author(s)
      中村真紀、入江路子、弓削亮太、市橋鋭也、飯島澄男、湯田坂雅子
    • Organizer
      第46回フラーレン・ナノチューブ・グラフェン総合シンポジウム
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] Gastrointestinal behavior of orally-administered single-walled carbon nanohorns

    • Author(s)
      中村真紀、田原善夫、村上達也、飯島澄男、湯田坂雅子
    • Organizer
      第43回フラーレン・ナノチューブ・グラフェン総合シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] 経口投与したカーボンナノホーンの挙動 ~経口薬剤キャリアへの応用に向けて~

    • Author(s)
      中村真紀、田原善夫、村上達也、飯島澄男、湯田坂雅子
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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