Development of a novel bioinformatics method to identify novel functional peptides in a genome and experimental verification of their anticancer effects
Project/Area Number |
24710222
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical genome science
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Research Institution | Chiba University |
Principal Investigator |
TAKAHASHI HIRO 千葉大学, 園芸学研究科, 准教授 (30454367)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | バイオインフォマティクス / 翻訳抑制 / がん / 情報工学 / 癌 / 医療・福祉 / 薬学 / 医療・福祉 |
Outline of Final Research Achievements |
The objectives are outlined in the title. Accordingly, we developed a novel bioinformatics method. This method was applicable to various genomes, and the function of the identified peptides was confirmed empirically by a transient in vitro assay. Moreover, we observed in vitro inhibition of growth of a sarcoma, murine sarcoma Sendai (MUSS) by 4E-BP peptides that inhibited the growth of various carcinomas in vitro.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Identification of novel Arabidopsis thaliana upstream open reading frames that control expression of the main coding sequences in a peptide sequence-dependent manner.2015
Author(s)
Ebina I, Takemoto-Tsutsumi M, Watanabe S, Koyama H, Endo Y, Kimata K, Igarashi T, Murakami K, Kudo R, Ohsumi A, Noh AL, Takahashi H, Naito S, Onouchi H
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Journal Title
Nucleic Acids Research
Volume: 43
Issue: 3
Pages: 1562-1576
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect2014
Author(s)
Takahashi H., Sai K., Saito Y., Kaniwa N., Matsumura Y., Hamaguchi T., Shimada Y., Ohtsu A., Yoshino T., Doi T., Okuda H., Ichinohe R., Takahashi A., Doi A., Odaka Y., Okuyama M., Saijo N., Sawada J., Sakamoto H., and Yoshida T.
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Journal Title
PLoS ONE
Volume: 9
Issue: 8
Pages: e105160-e105160
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Analysis of gene expression profiles of soft tissue sarcoma using a combination of knowledge-based filtering with integration of multiple statistics2014
Author(s)
Takahashi A., Nakayama R., Ishibashi N., Doi A., Ichinohe R., Ikuyo Y., Takahashi T., Marui S., Yasuhara K., Nakamura T., Sugita S., Sakamoto H., Yoshida T., Hasegawa T., and Takahashi H.
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Journal Title
PLoS ONE
Volume: 9
Issue: 9
Pages: e106801-e106801
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Predictive value of high-molecular weight adiponectin in subjects with a higher risk of the development of metabolic syndrome: From a population based 5-year follow-up data.2013
Author(s)
Kotooka N, Komatsu A, Takahashi H, Nonaka M, Kawaguchi C, Komoda H, Asaka M, Abe S, Taguchi I, Toyoda S, Nishiyama M, Inoue T, Node K.
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Journal Title
Int J Cardiol.
Volume: 167(3)
Issue: 3
Pages: 1068-70
DOI
Related Report
Peer Reviewed
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[Journal Article] Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: Potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses2013
Author(s)
Takahashi H., Nakayama R., Hayashi S., Nemoto T., Murase Y., Nomura K., Takahashi T., Kubo K., Marui S., Yasuhara K., Nakamura T., Sueo T., Takahashi A., Tsutsumiuchi K., Ohta T., Kawai A., Sugita S., Yamamoto S., Kobayashi T., Honda H., Yoshida T., Hasegawa T.
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Journal Title
PLoS ONE
Volume: 8
Issue: 10
Pages: e78250-e78250
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data2013
Author(s)
Takahashi H., Kaniwa N., Saito Y., Sai K., Hamaguchi T., Shirao K., Shimada Y., Matsumura Y., Ohtsu A., Yoshino T., Takahashi A., Odaka Y., Okuyama M., Sawada J., Sakamoto H. and Yoshida T.
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Journal Title
J. Biosci. Bioeng.
Volume: 116
Issue: 6
Pages: 768-773
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Berberine enhances defects in the establishment of leaf polarity in asymmetric leaves2 and asymmetric leaves1 of Arabidopsis thaliana2012
Author(s)
Nakagawa A, Takahashi H, Kojima S, Sato N, Ohga K, Cha BY, Woo J-T, Nagai K, Horiguchi G, Tsukaya H, Machida Y and Machida C
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Journal Title
Plant Mol Biol
Volume: 79
Issue: 6
Pages: 569-581
DOI
Related Report
Peer Reviewed
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[Presentation] Bioinformatic identification method of evolutional ranges for potential functional molecules on genomes2014
Author(s)
Takahashi H., Takahashi A., Takemoto M., Ebina I., Kimata K., Igarashi T., Kudo R., Osumi A., Naito S., and Onouchi H.
Organizer
The Problem of the Origin of Life
Place of Presentation
Moscow, Russia
Year and Date
2014-09-22 – 2014-09-26
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