| Project/Area Number |
24710234
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
UMEMURA Myco 独立行政法人産業技術総合研究所, 生物プロセス研究部門, 主任研究員 (00552259)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 大規模遺伝子発現情報 / 二次代謝経路 / 真菌類 / 培養条件 / 大規模遺伝子情報 / 代謝パターン |
|---|
| Research Abstract |
To rationally design culture conditions suitable for the production of fungal secondary metabolites, we built the method to analyze large-scale transcriptome datasets obtained under 190 kinds of nutrition conditions. We sum up and normalize gene induction ratios per pathway in each condition. The scores are further normalized in each pathway. Clustering analysis of the scores revealed that secondary metabolic pathways can be classified into mainly three groups, and each group has corresponding type of inducible nutrition conditions. Based on this result, more accurate and wide information for nutrition conditions inducing secondary metabolite production will be able to be obtained by applying this method to larger transcriptome datasets in public database.
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