| Project/Area Number |
24710242
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Glucan / biopolymers / conjugation / chemical synthesis / binding assays / Glycoconjugates / Solid-phase synthesis / Binding Assay / microarray / β-glucan / adjuvant / solid-phase synthesis / Dectin-1 / glycan microarray / binding assay / β -glucan / Glycan Microarray / Bioinformatic docking / Adjuvant |
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| Outline of Final Research Achievements |
The final aim of the project is to develop novel glycan-derivatives with application on immunotherapy.
During this term, the main investigator was able to follow the project based on beta-glucan conjugates. First, we focus on the developing of novel conjugates based on 1,3-beta-glucans. Immune system is able to recognize long glucans forming a triple helix structure; the aim is to mimic the same structure by using shorter polymers of beta-glucans conjugated with peptides. After challenging several drawbacks, the glycoconjugates were finally synthesized, finally structural and biological assays are undergoing.
This is a very challenging project including chemical synthesis on solid-phase, solution and biological evaluation, we got successful results and further studies are still undergoing. We are very confident to get a potential candidate as an immune system modulator. Further, this findings and novel approaches open avenues for broader applications.
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