DEVELOPING NOVEL VACCINE ADJUVANTS BASED ON BETA-GLUCAN
Project/Area Number |
24710242
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Living organism molecular science
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Research Institution | Hokkaido University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | Glucan / biopolymers / conjugation / chemical synthesis / binding assays / Glycoconjugates / Solid-phase synthesis / Binding Assay / microarray / β-glucan / adjuvant / solid-phase synthesis / Dectin-1 / glycan microarray / binding assay / β -glucan / Glycan Microarray / Bioinformatic docking / Adjuvant |
Outline of Final Research Achievements |
The final aim of the project is to develop novel glycan-derivatives with application on immunotherapy. During this term, the main investigator was able to follow the project based on beta-glucan conjugates. First, we focus on the developing of novel conjugates based on 1,3-beta-glucans. Immune system is able to recognize long glucans forming a triple helix structure; the aim is to mimic the same structure by using shorter polymers of beta-glucans conjugated with peptides. After challenging several drawbacks, the glycoconjugates were finally synthesized, finally structural and biological assays are undergoing. This is a very challenging project including chemical synthesis on solid-phase, solution and biological evaluation, we got successful results and further studies are still undergoing. We are very confident to get a potential candidate as an immune system modulator. Further, this findings and novel approaches open avenues for broader applications.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR2015
Author(s)
Helena Coelho, Matsushita T., Gerard Artigas, Hiroshi H., F. Javier Cañada, Richard Lo-Man, Claude Leclerc, Eurico J. Cabrita, Jesús Jiménez-Barbero, Nishimura S-I., Fayna Garcia-Martín, and Filipa Marcelo
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Journal Title
J. Am. Chem. Soc.
Volume: 137
Issue: 39
Pages: 12438-12441
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Delineating binding modes of Gal/GalNAc and structural elements of the molecular recognition of tumor-associated mucin glycopeptides by the human macrophage galactose-type lectin2014
Author(s)
Filipa Marcelo, Fayna Garcia-Martin, Takahiko Matsushita, Joao Sardinha, Helena Coelho, Anneloes Oude-Vrielink, Christiane Koller, Sabine Andre, Eurico J Cabrita, Hans-Joachim Gabius, Shin-ichiro Nishimura, Jesus Jimenez-Barbero, and F Javier Canada
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Journal Title
Chemistry, an European Journal
Volume: 20
Issue: 49
Pages: 16147-16155
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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