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Synthetic Approach toward the Structural Elucidation of the Natural Products

Research Project

Project/Area Number 24710250
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Living organism molecular science
Research InstitutionOkayama University

Principal Investigator

TAKAMURA Hiroyoshi  岡山大学, 自然科学研究科, 准教授 (70422798)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords有機化学 / 合成化学 / 天然物化学 / 立体化学 / 構造解明 / 構造活性相関
Outline of Final Research Achievements

Organic compounds which exist in nature, so-called natural products have been positioned as the useful drug candidates due to their potent biological activities. Structural elucidation of the natural products is not only the fundamental but also significant research theme in the natural product chemistry. In this research, we have tried the synthetic approach toward the structural determination of the natural products whose stereostructures have not been elucidated.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (22 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Invited: 2 results)

  • [Journal Article] Stereodivergent Synthesis and Relative Stereostructure of the C1-C13 Fragment of Symbiodinolide2015

    • Author(s)
      Hiroyoshi Takamura, Hiroko Wada, Mao Ogino, Takahiro Kikuchi, Isao Kadota, Daisuke Uemura
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 80 Issue: 6 Pages: 3111-3123

    • DOI

      10.1021/acs.joc.5b00027

    • NAID

      120006522866

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 構造解明を指向したポリオール天然物シンビオジノライドの合成研究2014

    • Author(s)
      高村浩由、門田功、上村大輔
    • Journal Title

      有機合成化学協会誌

      Volume: 72 Pages: 2-13

    • NAID

      130003395366

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Synthesis of the C79-C97 Fragment of Symbiodinolide2013

    • Author(s)
      Hiroyoshi Takamura, Takayuki Fujiwara, Isao Kadota, Daisuke Uemura
    • Journal Title

      Beilstein Journal of Organic Chemistry

      Volume: 9 Pages: 1931-1935

    • DOI

      10.3762/bjoc.9.228

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis, Structural Elucidation, and Structure–Cytotoxic Activity Relationship of (–)-Gummiferol2013

    • Author(s)
      Hiroyoshi Takamura, Hiroko Wada, Nan Lu, Osamu Ohno, Kiyotake Suenaga, Isao Kadota
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 78 Issue: 6 Pages: 2443-2454

    • DOI

      10.1021/jo302665c

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of Two Possible Diastereomers of (+)-Sarcophytonolide C and Its Structural Elucidation2013

    • Author(s)
      Total Synthesis of Two Possible Diastereomers of (+)-Sarcophytonolide C and Its Structural Elucidation
    • Journal Title

      Org. Lett

      Volume: 15 Issue: 5 Pages: 1108-1111

    • DOI

      10.1021/ol400157s

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stereoselective synthesis of the C94-C104 fragment of symbiodinolide2012

    • Author(s)
      H. Takamura, K. Tsuda, Y. Kawakubo, I. Kadota, D. Uemura
    • Journal Title

      Tetrahedron Letters

      Volume: 53 Issue: 33 Pages: 4317-4319

    • DOI

      10.1016/j.tetlet.2012.06.005

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 立体構造決定を目的とした6-クロロテトラヒドロフランアセトゲニンの合成研究2015

    • Author(s)
      岡本和樹、高村浩由、門田功
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学船橋キャンパス(船橋市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] (-)-ダクチロライドの合成研究2015

    • Author(s)
      田中睦大、村井勇斗、高村浩由、門田功
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学船橋キャンパス(船橋市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] サルコフィトノライドHの全合成2015

    • Author(s)
      菊地崇浩、高村浩由、門田功
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学船橋キャンパス(船橋市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 合成化学的手法を用いた立体構造未解明天然物の構造決定2014

    • Author(s)
      高村浩由
    • Organizer
      2014年日本化学会中国四国支部大会
    • Place of Presentation
      山口大学吉田キャンパス(山口市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] シンビオジノライドC1-C13フラグメントの立体発散的合成と相対立体構造2014

    • Author(s)
      高村浩由、和田寛子、荻野真生、門田功、上村大輔
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知県立県民文化ホール(高知市)
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] (-)-Dactylolideの合成研究2014

    • Author(s)
      田中睦大、村井勇斗、高村浩由、門田功
    • Organizer
      第30回若手化学者のための化学道場(岡山2014)
    • Place of Presentation
      下電ホテル(倉敷市)
    • Year and Date
      2014-08-29 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] サルコフィトノライドHの全合成と細胞毒性2014

    • Author(s)
      菊地崇浩、高村浩由、門田功
    • Organizer
      第30回若手化学者のための化学道場(岡山2014)
    • Place of Presentation
      下電ホテル(倉敷市)
    • Year and Date
      2014-08-29 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Total Synthesis of Two Possible Diastereomers of (+)-Sarcophytonolide C and Its Absolute Configurational Elucidation2014

    • Author(s)
      Hiroyoshi Takamura, Kohei Iwamoto, Eiji Nakao, Isao Kadota
    • Organizer
      International Symposia on Advancing the Chemical Sciences (ISACS) 14
    • Place of Presentation
      上海(中国)
    • Year and Date
      2014-08-07 – 2014-08-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] シンビオジノライドC94-C104フラグメントの立体発散的合成2014

    • Author(s)
      川久保陽平、藤原敬之、高村浩由、門田功、上村大輔
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Related Report
      2013 Research-status Report
  • [Presentation] サルコフィトノライドFの全合成2014

    • Author(s)
      仲尾英史、高村浩由、門田功
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Related Report
      2013 Research-status Report
  • [Presentation] スカブロライドFの合成研究2014

    • Author(s)
      森下諒平、高村浩由、門田功
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Related Report
      2013 Research-status Report
  • [Presentation] シンビオジノライドC1-C13フラグメントの立体発散的合成2014

    • Author(s)
      荻野真生、和田寛子、高村浩由、門田功、上村大輔
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Related Report
      2013 Research-status Report
  • [Presentation] (-)-グンミフェロールの全合成・構造決定・構造活性相関2013

    • Author(s)
      高村浩由、和田寛子、呂楠、大野修、末永聖武、門田功
    • Organizer
      第55回天然有機化合物討論会
    • Place of Presentation
      同志社大学寒梅館
    • Related Report
      2013 Research-status Report
  • [Presentation] (-)-グンミフェロールの全合成・構造決定・構造活性相関2013

    • Author(s)
      高村浩由、和田寛子、呂楠、大野修、末永聖武、門田功
    • Organizer
      第104回有機合成シンポジウム
    • Place of Presentation
      早稲田大学国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 生物活性を有する天然有機化合物の全合成と構造解明2013

    • Author(s)
      高村浩由
    • Organizer
      第36回有機合成化学協会中国四国支部奨励賞受賞講演会
    • Place of Presentation
      広島大学東広島キャンパス
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Total Synthesis and Absolute Configuration of (-)-Gummiferol2012

    • Author(s)
      Hiroyoshi Takamura
    • Organizer
      The 6th Takeda Science Foundation Symposium on PharmaSciences "How Fascinating the Synthetic Organic Chemistry Is!"
    • Place of Presentation
      Center for Learning and Innovation, Takeda Pharmaceutical Company Ltd, Suita, Japan
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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