Development of synthetic small molecules that control the lipid biosynthesis
| Project/Area Number |
24710260
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 構造活性相関 / 脂質代謝 / ケミカルバイオロジー / 医薬品化学 / 有機合成化学 / 化合物ライブラリー / 脂質代謝制御 |
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| Research Abstract |
Various small molecules based on the structure of "fatostatin", which was a synthetic molecule identified by our research group that inhibits a lipid biosynthetic pathway, were designed and synthesized. The inhibitory effects of these synthesized molecules on the important protein for the lipid biosynthesis were evaluated by the cell-based reporter assay. As a result, a new small molecule that shows more potent inhibitory effects on the lipid biosynthesis pathway than previous ones was obtained. Now, its detail function in cells are investigated.
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Report
(3 results)
Research Products
(18 results)
