| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Various small molecules based on the structure of "fatostatin", which was a synthetic molecule identified by our research group that inhibits a lipid biosynthetic pathway, were designed and synthesized. The inhibitory effects of these synthesized molecules on the important protein for the lipid biosynthesis were evaluated by the cell-based reporter assay. As a result, a new small molecule that shows more potent inhibitory effects on the lipid biosynthesis pathway than previous ones was obtained. Now, its detail function in cells are investigated.
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