| Project/Area Number |
24710267
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Osaka University (2013)
The Institute of Physical and Chemical Research (2012) |
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Principal Investigator |
ANDO Jun 大阪大学, 工学(系)研究科(研究院), 特任研究員 (40623369)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ラマン分光法 / 薬剤標識タンパク質 / 表面増強ラマン散乱 / 質量分析法 / 液体クロマトグラフィー / タンパク質 / 小分子 / 薬剤標識 / 薬剤標的タンパク質 |
|---|
| Research Abstract |
Functions of proteins working in a biological cell is regulated by the binding with various kinds of small molecules. Identification of specific proteins, which bind with the small molecules, and the information of their binding mechanism at molecular level, will largely contribute for the drug discovery and the study of protein function. However, complexity of biological samples often prevent to analyze them. In this research, the construction of the system was considered that can combine Raman spectroscopy with liquid chromatography. Since Raman spectroscopy has a variety of chemical information, it will contribute to analyze the samples, which are under fractionation with liquid chromatography.
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