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Functional analysis for PKC which localized on organelle utilizing fatty acid-induced cell death

Research Project

Project/Area Number 24710268
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Chemical biology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

TAMURA Yuki  独立行政法人理化学研究所, 袖岡有機合成化学研究室, 客員研究員 (50442984)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsプロテインキナーゼC / 脂肪酸 / 細胞死 / プロテインキナーゼC / リン酸化
Research Abstract

GLA-induced translocation of several PKC subtypes were observed under fluorescence microscope, and PKCdelta and zeta localized around the nucleus in HeLa cells. Fatty acids accumulated as lipid droplet around the nucleus, which were confirmed by using Nile Red staining and Raman microscope. However, translocated PKCdelta did not seem to co-localize with lipid droplets, suggesting that PKCdelta did not translocate to lipid droplets and might localize at the other organelles such as Golgi apparatus, Endoplasmic reticulum or mitochondria.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2012

All Presentation (2 results)

  • [Presentation] 新規PKCalpha活性化阻害剤IB-15Aの構造活性相関と作用機序解明研究2012

    • Author(s)
      田村結城, 平井剛, 酒井基成, 大窪恵, 袖岡幹子
    • Organizer
      日本ケミカルバイオロジー学会第七回年会
    • Place of Presentation
      京都
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] PKCalpha活性化阻害剤IB-15Aの構造活性相関と作用機序解明研究2012

    • Author(s)
      田村 結城,平井 剛,酒井 基成,大窪 恵,袖岡 幹子
    • Organizer
      日本ケミカルバイオロジー学会 第7回年会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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