Developmental change of brain function and influence of intervention in childhood.

• Project/Area Number: 24730531
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Educational psychology
• Research Institution: University of Fukui
• Principal Investigator: Daisuke Saito 福井大学, 子どものこころの発達研究センター, 特命准教授 (30390701)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: fMRI / MRI / Attention Network Test / 発達 / 脳機能 / 脳機能イメージング / 注意機能 / 介入 / 認知機能 / 注意 / 抑制 / 運動

Outline of Final Research Achievements

We investigated brain development from childhood to adulthood using functional magnetic resonance imaging (fMRI) technique. Aim of this study was investigate developmental changes of the attentional ability from a childhood to the adulthood and clarify the intervention that improves its ability.
We estimated the brain function and structure associate with the attentional ability and clarify the age-related changes about brain activity, brain volume and neural network. Furthermore, the correlation of cognitive task performance and hormonal level showed that everyday life environment and a habit were concerned with cognitive function and hormone level, and it became clear to affect the brain function.

Research Products

• [Journal Article] Autistic empathy toward autistic others (2015)
  • Author(s): Komeda H, Kosaka H, Saito DN, Mano Y, Jung M, Fujii T, Yanaka HT, Munesue T, Ishitobi M, Sato M, Okazawa H
  • Journal Title: Social cognitive and affective neuroscience Volume: 10 (2) Issue: 2 Pages: 145-52
  • DOI: 10.1093/scan/nsu126
  • Peer Reviewed / Open Access
• [Journal Article] Reduced visual cortex gray matter volume in children and adolescents with reactive attachment disorder. (2015)
  • Author(s): Shimada K, Takiguchi S, Mizushima S, Fujisawa TX, Saito DN, Kosaka H, Okazawa H, Tomoda A.
  • Journal Title: Neuroimage-Clinical Volume: 9 Pages: 13-19
  • DOI: 10.1016/j.nicl.2015.07.001
  • Peer Reviewed / Open Access
• [Journal Article] Neural basis of psychological growth following adverse experiences: A resting-state functional MRI study. (2015)
  • Author(s): Fujisawa TX, Jung M, Kojima M, Saito DN, Kosaka H, Tomoda A.
  • Journal Title: PLoS One Volume: 10 Issue: 8 Pages: e0136427-e0136427
  • DOI: 10.1371/journal.pone.0136427
  • NAID: 120005756533
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 簡易視線追跡装置「GazeFinder®」の思春期・青年期男性における妥当性検証 (2015)
  • Author(s): 藤岡 徹、岡本 悠子、升谷 泰裕、石飛 信、浅野 みずき、齋藤 大輔、丁 ミンヨン、松村 由紀子、藤澤 隆史、小泉 径子、鈴木 勝昭、土屋 賢治、森 則夫、片山 泰一、棟居 俊夫、友田 明美、小坂 浩隆.
  • Organizer: 第56回日本児童青年精神医学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-09-30
• [Presentation] 自閉スペクトラム症特性に関する、Defaolt mode networkの性差 (2015)
  • Author(s): 水野 賀史、丁 ミンヨン、齋藤 大輔、友田 明美、小坂 浩隆.
  • Organizer: 第56回日本児童青年精神医学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-09-30
• [Presentation] Shared right inferior fronto-parietal substrates for corporeal awareness and self-identification. (2015)
  • Author(s): Morita T, Saito DN, Ban M, Shimada K, Okamoto Y, Kosaka H, Okazawa H, Asada M, Naito E.
  • Organizer: 21st Annual Meeting Of The Organization For Human Brain Mapping
  • Place of Presentation: Hawaii
  • Year and Date: 2015-06-16
  • Int'l Joint Research
• [Presentation] Male brain is more affected by autism spectrum traits than female. (2015)
  • Author(s): Jung M, Saito DN, Tomoda A, Okazawa H, Wada Y, Kosaka H.
  • Organizer: 21st Annual Meeting Of The Organization For Human Brain Mapping
  • Place of Presentation: Hawaii
  • Year and Date: 2015-06-16
  • Int'l Joint Research
• [Presentation] Association between functional connectivity of default-mode brain and personal growth from adversity. (2015)
  • Author(s): Fujisawa TX, Jung M, Kojima M, Saito DN, Kosaka H, Tomoda A.
  • Organizer: 21st Annual Meeting Of The Organization For Human Brain Mapping
  • Place of Presentation: Hawaii
  • Year and Date: 2015-06-15
  • Int'l Joint Research
• [Presentation] 発達障害の先端的研究－子どものこころのセンターの取り組み (2015)
  • Author(s): 齋藤 大輔
  • Organizer: 第57回日本小児神経学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-05-29
  • Invited
• [Presentation] 自閉症スペクトラム障害（ＡＳＤ）の安静時脳内ネットワークの特徴 (2014)
  • Author(s): 丁 ミンヨン、齋藤 大輔、岡本 悠子、藤岡 徹、棟居 俊夫、 友田 明美、岡沢 秀彦、小坂 浩隆
  • Organizer: 第41回日本脳科学会大会
  • Place of Presentation: 福井県県民ホール
  • Year and Date: 2014-11-22 – 2014-11-23
• [Presentation] 自閉症スペクトラム障害者における扁桃体の安静時脳活動 (2014)
  • Author(s): 丁 ミンヨン、齋藤 大輔、石飛 信、守田 知代、猪原 敬介、佐々木 章宏、新井 清義、升谷 泰裕、藤岡 徹、岡本 悠子、棟居 俊夫、友田 明美、定藤 規弘、岡沢 秀彦、飯高 哲也、和田 有司、小坂 浩隆
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Functional connectivity in default mode network predicts autism spectrum traits ? (2014)
  • Author(s): Minyoung Jung, Hirotaka Kosaka, Daisuke N. Saito, Makoto Ishitobi, Tomoyo Morita, Keisuke Inohara, Akihiro Sasaki, Mizuki Asano, Sumiyoshi Arai, Yasuhiro Masuya, Toshio Munesue, Akemi Tomoda, Yuji Wada, Norihiro Sadato, Hidehiko Okazawa, Tetsuya Iidaka
  • Organizer: Human Brain Mapping
  • Place of Presentation: CCH-Congress Center in Hamburg, Germany
  • Year and Date: 2014-06-08 – 2014-06-12
• [Presentation] Developmental changes of attention ability in children and adolescents (2014)
  • Author(s): Daisuke N. Saito, Hisakazu Ymaka, Takeshi Fujii, Hirotaka Kosaka, Noriko Muramatsu, Kyoko Matsumura, Makoto Sato, Hidehiko Okazawa
  • Organizer: International Workshop on Molecular Functional Imaging for Brain and Gynecologic Oncology
  • Place of Presentation: ユアーズホテル福井, 福井, Japan
• [Presentation] fMRI study of the reward system of pediatric patients with Reactive Attachment Disorder (2014)
  • Author(s): Shinichiro Takiguchi, Takeshi X. Fujisawa, Daisuke N. Saito, Chiho Yatsuga, Hirokazu Kumazaki, Sakae Mizushima, Toshiya Aoi, Masahiko Kojima, Hiroaki Naruse, Michiko Koizumi, Minyoung Jung, Hirotaka Kosaka, Akemi Tomoda
  • Organizer: International Workshop on Molecular Functional Imaging for Brain and Gynecologic Oncology
  • Place of Presentation: ユアーズホテル福井, 福井, Japan
• [Presentation] The development of attentional network during childhood and adult: an fMRI study (2013)
  • Author(s): Daisuke N. Saito, Hisakazu Yanaka, Takeshi Fujii, Hirotaka Kosaka, Tomoko Muramatsu, Taisuke Shimada, Kyoko Matsumura, Makoto Sato, Hidehiko Okazawa
  • Organizer: Human Brain Mapping
  • Place of Presentation: Seattle, U.S.
• [Presentation] 注意に関する神経基盤の発達：Voxel-Based Morphometry研究 (2013)
  • Author(s): 藤井 猛，齋藤 大輔，谷中 久和，小坂 浩隆，村松 倫子，岡沢 秀彦
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館, 京都, Japan
• [Book] 発達科学ハンドブック 第8巻『脳の発達科学』 (2015)
  • Author(s): 齋藤 大輔 共著
  • Total Pages: 317
  • Publisher: 新曜社
• [Book] 子どものこころと脳の発達 第5巻1号 (2014)
  • Author(s): 大阪大学大学院大阪大学・金沢大学・浜松医科大学・千葉大学・福井大学連合小児発達学研究科
  • Total Pages: 72
  • Publisher: 金芳堂
• [Book] 心の発達の研究最前線：脳科学の観点から－fMRIを中心に (2013)
  • Author(s): 滝口 慎一郎, 齋藤 大輔, 小坂 浩隆, 友田 明美
  • Total Pages: 5
  • Publisher: 小児内科
• [Book] 自閉症スペクトラム障害の社会性障害を探る: fMRI 研究 (2013)
  • Author(s): 小坂 浩隆, 田邊宏樹, 守田知代, 岡本悠子, 齋藤 大輔, 石飛 信, 棟居 俊夫, 和田 有司, 定藤規弘
  • Total Pages: 6
  • Publisher: 日本生物学的精神医学会誌