Cognitive dysfunction in patients with Alzheimer's disease and amnestic mild cognitive impairment showing hemispheric asymmetries of hypometabolism on 18F-FDG PET
| Project/Area Number |
24730594
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical psychology
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| Research Institution | Kitasato University |
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Principal Investigator |
MURAYAMA Norio 北里大学, 医療衛生学部, 准教授 (00617243)
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| Research Collaborator |
ISEKI Eizo
ENDO Tadashi
OTA Kazumi
KANEEDA Kyoko
KISHIMOTO Azusa
HIRONAKA Tomoko
MATSUNAGA Yusuke
YAMAGATA Mayumi
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 心理アセスメント / 認知症 / アルツハイマー病 / 記憶機能 / 臨床心理学 / 軽度認知障害 / 認知機能障害 / 脳糖代謝 |
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| Outline of Final Research Achievements |
We investigated cognitive dysfunction in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) who present hemispheric asymmetries of cerebral metabolic rate of glucose (CMRglc) decrease on 18 F-fluorodeoxyglucose positron emission tomography. Based on the hemispheric asymmetries of CMRglc decrease in the posterior cingulate cortex, precuneus, and parietotemporal cortex, the patients were divided into three groups (a left-dominant hypometabolism group, a right-dominant hypometabolism group, and a non-dominant hypometabolism group). As a result, there were no significant differences in MMSE and WAIS-III scores among the three groups. In WMS-R, the results indicated that the left-dominant group demonstrated significantly lower scores in verbal memory than the other two groups.
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Report
(4 results)
Research Products
(28 results)
