| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Since the spatiotemporal dynamics of the frontal neuronal activity after the stimulation of the basal forebrain is unknown, we addressed this issue by using voltage-sensitive dye imaging of frontal neural activity evoked by electrical stimulation of the basal forebrain. As a result, voltage-sensitive dye imaging represented by a single-pulse stimulation of the basal forebrain elicited a short-latency excitatory response in the frontal cortex. After application of the acetylcholine receptor antagonist, neural response was spread across a wide area of the frontal cortex and presented a prolonged latency, compared to control condition. Meanwhile, the excitatory response was blocked after the glutamate receptor antagonist application. These results suggested that the basal forebrain-evoked specific excitatory response was attributed to the interaction of cholinergic and glutamatergic projections in the frontal cortex.
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