Effect of the neuromodulator in the prefrontal cortex
| Project/Area Number |
24730641
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental psychology
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Watanabe Yumiko 国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (20425739)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 前頭前野 / アセチルコリン / 光イメージング / ドーパミン |
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| Outline of Final Research Achievements |
Since the spatiotemporal dynamics of the frontal neuronal activity after the stimulation of the basal forebrain is unknown, we addressed this issue by using voltage-sensitive dye imaging of frontal neural activity evoked by electrical stimulation of the basal forebrain. As a result, voltage-sensitive dye imaging represented by a single-pulse stimulation of the basal forebrain elicited a short-latency excitatory response in the frontal cortex. After application of the acetylcholine receptor antagonist, neural response was spread across a wide area of the frontal cortex and presented a prolonged latency, compared to control condition. Meanwhile, the excitatory response was blocked after the glutamate receptor antagonist application. These results suggested that the basal forebrain-evoked specific excitatory response was attributed to the interaction of cholinergic and glutamatergic projections in the frontal cortex.
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Report
(5 results)
Research Products
(8 results)
