Behavioral study on the combination therapy of anti-dementia drug
| Project/Area Number |
24730642
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental psychology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Yanai Shuichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60469070)
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| Research Collaborator |
Endo Shogo
Arasaki Tomoko
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 記憶・学習 / 老化 / 多剤併用療法 / シロスタゾール / ドネペジル / 記憶 / 学習 / Cilostazol / Phosphodiesterase (PDE) / 認知症 / アルツハイマー病 |
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| Outline of Final Research Achievements |
In the present study, we revealed that the PDE3 inhibitor cilostazol improved the impaired learning and memory function in aged C57BL/6J mice and senescence-accelerated mouse prone 8 (SAMP8) to the same extent as young mice. Based on these findings, a clinical trial is now underway in Japan to gain approval for the use of cilostazol in treating mild cognitive impairment.
In addition, sub-effective dose of cilostazol and donepezil in combination enhances learning and memory function in aged C57BL/6J mice. These results suggest that the combination therapy comprising two or more drugs may offer a new pharmacological approach for treating cognitive disorders, as the combination therapy demonstrated to be an effective strategy for treating some types of diseases.
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Report
(5 results)
Research Products
(30 results)
