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Role of hydration water on the self-assembly of lipids

Research Project

Project/Area Number 24740289
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biophysics/Chemical physics
Research InstitutionUniversity of Tsukuba

Principal Investigator

HISHIDA Mafumi  筑波大学, 数理物質系, 助教 (70519058)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords水の役割 / 自己組織化 / 脂質膜 / 水和状態 / テラヘルツ分光 / X線小角散乱 / 脂質二重膜 / 自己組織化構造形成 / 水和水 / 水和 / 相転移 / ソフトマター / 生体膜
Outline of Final Research Achievements

For long, water has been considered as just a background medium for the self-assembly of soft matter including biomolecules. However, the present study clarified that structural changes of phospholipid bilayers strongly depends on their hydration states from the measurements of terahertz spectroscopy and small angle-X-ray scattering. Further, ion-dependence of stacking structure of phospholipid membranes revealed that water has some “role” for the interactions between the membranes.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (31 results)

All 2015 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (24 results) (of which Invited: 3 results) Remarks (2 results)

  • [Journal Article] Interplay between Phase Transition of DPPC Bilayer and Photoisomerization of Doped Stilbene Molecule2014

    • Author(s)
      Koyomi Nakazawa, Mafumi Hishida, Shigenori Nagatomo, Yasuhisa Yamamura, Kazuya Saito
    • Journal Title

      Chem. Lett.

      Volume: 43 Issue: 8 Pages: 1352-1354

    • DOI

      10.1246/cl.140398

    • NAID

      130004677583

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Salt Effects on Lamellar Repeat Distance Depending on Head Groups of Neutrally Charged Lipids2014

    • Author(s)
      Mafumi Hishida, Yasuhisa Yamamura, Kazuya Saito
    • Journal Title

      Langmuir

      Volume: 30 Issue: 35 Pages: 10583-10589

    • DOI

      10.1021/la502576x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] リン脂質・界面活性剤の水和状態と構造形成の相関2014

    • Author(s)
      菱田真史
    • Journal Title

      C&I Commun.

      Volume: 39 Pages: 17-19

    • NAID

      40020460142

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperativity between Water and Lipids in Lamellar to Inverted-Hexagonal Phase Transition2014

    • Author(s)
      Mafumi Hishida, Koichiro Tanaka, Yasuhisa Yamamura, Kazuya Saito
    • Journal Title

      J. Phys. Soc. Jpn.

      Volume: 83 Issue: 4 Pages: 44801-44801

    • DOI

      10.7566/jpsj.83.044801

    • NAID

      120007136234

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transition of the hydration state of a surfactant accompanying structural transitions of self-assembled aggregates2012

    • Author(s)
      M. Hishida, K. Tanaka
    • Journal Title

      J. Phys.: Condens. Matter

      Volume: 24 Issue: 28 Pages: 284113-284113

    • DOI

      10.1088/0953-8984/24/28/284113

    • NAID

      120007137280

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] アルカンの添加によるリン脂質膜ベシクルの硬化と破裂2015

    • Author(s)
      菱田真史,柳澤隆大,山村泰久,齋藤一弥
    • Organizer
      第70回日本物理学会年次大会
    • Place of Presentation
      早稲田大学早稲田キャンパス
    • Year and Date
      2015-03-21 – 2015-03-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Stiffening of Lipid bilayer by n-alkane2015

    • Author(s)
      M. Hishida, A. Endo, R. Yanagisawa, K. Nakazawa, Y. Yamamura, K. Saito
    • Organizer
      Physics of Structural and Dynamical Hierarchy in Soft Matter
    • Place of Presentation
      東京大学生産技術研究所
    • Year and Date
      2015-03-16 – 2015-03-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] リン脂質二重膜に対するアルカンの添加効果:膜の硬化と破裂2015

    • Author(s)
      菱田真史,遠藤麻未,柳澤隆大,中澤暦,山村泰久,齋藤一弥
    • Organizer
      第4回ソフトマター研究会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2015-01-06 – 2015-01-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] リン脂質二重膜に対するアルカンの添加効果:頭部構造依存性と膜の硬化2014

    • Author(s)
      菱田真史,遠藤麻未,柳澤隆大,山村泰久,長友重紀,齋藤一弥
    • Organizer
      第50回記念熱測定討論会
    • Place of Presentation
      大阪大学豊中キャンパス
    • Year and Date
      2014-09-28 – 2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] リン脂質膜のゲル液晶相転移に対する添加アルカンの効果2014

    • Author(s)
      菱田真史、遠藤麻未、柳澤隆大、山村泰久、長友重紀、齋藤一弥
    • Organizer
      日本物理学会2014年秋季大会
    • Place of Presentation
      中部大学
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中性リン脂質二重膜の膜間相互作用に対する塩の添加効果2014

    • Author(s)
      菱田真史、山村泰久、齋藤一弥
    • Organizer
      日本物理学会第69回年次大会
    • Place of Presentation
      東海大学(神奈川)
    • Related Report
      2013 Research-status Report
  • [Presentation] 中性リン脂質のラメラ構造に対する添加塩の効果:イオン種依存性2013

    • Author(s)
      菱田真史、田中耕一郎、山村泰久、長友重紀、齋藤一弥
    • Organizer
      第12回関東ソフトマター研究会
    • Place of Presentation
      お茶の水大学(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] 添加塩のイオン種に依存した中性リン脂質の膜間相互作用の変化2013

    • Author(s)
      菱田真史、瀬戸秀紀、山村泰久、齋藤一弥
    • Organizer
      日本物理学会2013年秋季大会
    • Place of Presentation
      徳島大学(徳島)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脂質膜の膜融合に際する水の協同性2013

    • Author(s)
      菱田真史、田中耕一郎、山村泰久、齋藤一弥
    • Organizer
      第64回コロイドおよび界面化学討論会
    • Place of Presentation
      名古屋工業大学(名古屋)
    • Related Report
      2013 Research-status Report
  • [Presentation] Water-lipid cooperativity upon lipid membrane fusion2013

    • Author(s)
      菱田真史、田中耕一郎、山村泰久、齋藤一弥
    • Organizer
      第 51 回日本生物物理学会年会
    • Place of Presentation
      京都国際会館(京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] リン脂質二重膜表面において長距離に渡って存在する水和水の熱的状態2013

    • Author(s)
      菱田真史、山村泰久、長友重紀、齋藤一弥
    • Organizer
      第49回熱測定討論会
    • Place of Presentation
      千葉工業大学(千葉)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脂質膜の長距離水和層における水の熱的状態2013

    • Author(s)
      菱田真史、山村泰久、齋藤一弥
    • Organizer
      第三回ソフトマター研究会
    • Place of Presentation
      首都大学東京(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脂質の水和状態と構造形成の相互連関2013

    • Author(s)
      菱田真史
    • Organizer
      "CROSS研究会:CROSSroads of Users and J-PARC 第10回「生体膜・コロイド研究の最前線」"
    • Place of Presentation
      J-PARC(茨城)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] "Cooperativity between water and lipid upon lipid membrane fusion "2013

    • Author(s)
      M. Hishida, K. Tanaka, Y. Yamamura, S. Nagatomo, K. Saito
    • Organizer
      Light and Particle Beams in Materials Science 2013: LPBMS2013
    • Place of Presentation
      つくば国際会議場(つくば)
    • Related Report
      2013 Research-status Report
  • [Presentation] Thermal property of water in the long-range hydration layer of phospholipid membrane2013

    • Author(s)
      Mafumi Hishida, Yasuhisa Yamamura, Kazuya Saito
    • Organizer
      The Fifth International Symposium on the New Frontiers of Thermal Studies of Materials
    • Place of Presentation
      横浜情報文化センター(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] Hydration states of lipid and surfactant depending on their self-assemble structures and chemical species of the head groups

    • Author(s)
      Mafumi Hishida, Koichiro Tanaka
    • Organizer
      International Association of Colloid and Interface Scientists, Conference
    • Place of Presentation
      仙台国際センター
    • Related Report
      2012 Research-status Report
  • [Presentation] Correlation between hydration states and self-assembled structures of amphiphilic molecules studied by THz spectroscopy

    • Author(s)
      Mafumi Hishida, Koichiro Tanaka
    • Organizer
      14th International Conference on Organized Molecular Films
    • Place of Presentation
      Saints Peres Universuity (パリ、フランス)
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂質・界面活性剤の水和状態と構造形成 :テラヘルツ分光法を用いた研究から

    • Author(s)
      菱田真史、田中耕一郎、山村泰久、長友重紀、齋藤一弥
    • Organizer
      つくばソフトマター研究会2012
    • Place of Presentation
      高エネルギー加速器研究機構(東海)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] テラヘルツ分光法により見える生体分子の自己組織化における水の役割  ~脂質・界面活性剤の構造化と水分子ダイナミクス~

    • Author(s)
      菱田真史、田中耕一郎
    • Organizer
      テラヘルツ分光法の最先端 VI ~ここまできたテラヘルツ時間領域分光~
    • Place of Presentation
      筑波大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂質・界面活性剤の水和状態と構造形成:テラヘルツ分光法を用いた研究から

    • Author(s)
      菱田真史
    • Organizer
      日本液晶学会 液晶物理・物性フォーラム/ソフトマターフォーラム共催研究会
    • Place of Presentation
      東陽テクニカ本社(東京)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Water cooperativity upon lipid membrane fusion

    • Author(s)
      M. Hishida, K. Tanaka, Y. Yamamura, S. Nagatomo, K. Saito
    • Organizer
      筑波大学戦略イニシアティブ(A) 機能物質創製研究拠点主催「第3回国際シンポジウム」
    • Place of Presentation
      筑波大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Water cooperativity upon lipid membrane fusion

    • Author(s)
      M. Hishida, K. Tanaka, Y. Yamamura, S. Nagatomo, K. Saito
    • Organizer
      Self-organization and Emergent Dynamics in Active Soft Matter
    • Place of Presentation
      京都大学
    • Related Report
      2012 Research-status Report
  • [Presentation] リン脂質二重膜の膜融合に際する水の協同性

    • Author(s)
      菱田真史、田中耕一郎、山村泰久、長友重紀、齋藤一弥
    • Organizer
      物構研サイエンスフェスタ
    • Place of Presentation
      つくば国際会議場(エポカルつくば)
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂質膜の融合に際する水の協同性

    • Author(s)
      菱田真史、田中耕一郎、山村泰久、長友重紀、齋藤一弥
    • Organizer
      日本物理学会第68回年次大会
    • Place of Presentation
      広島大学
    • Related Report
      2012 Research-status Report
  • [Remarks] 菱田真史ホームページ

    • URL

      https://sites.google.com/site/mafumihishida/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 菱田真史のホームページ

    • URL

      https://sites.google.com/site/mafumihishida/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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