| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
In order to develop a practical method for the construction of crud like and heterocyclic compounds, we have designed a novel Passerini or Ugi reaction system where a compound (which we write in the general form as Z-X) composed of an electrophilic (Z) and nucleophilic (X) could perform the same reactivity as the carboxylic acid. Based on this concept, we have developed the O-silylative Passerini reaction and the borinic acid catalyzed addition of isocyanides to aldehydes. In addition, we have designed and demonstrated the addition reaction of isocyanides to nitrones in the presence of silly halide. Furthermore, a novel [5+1] cycloaddition of isocyanide was explored to afford the hetelocyclic compounds efficiency.
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