| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
Amide functional groups are found in a wide variety of organic molecules including pharmaceuticals and functional materials. Therefore, efficient synthesis of amide bonds has been extensively studied. On the other hand, transformation of the generated amide groups is less explored than their construction.
In this study, we developed direct nucleophilic addition to amide groups using unique properties of a zirconium reagent. The developed method enabled installation of two functional groups in a single reaction. The most conspicuous feature of our method is the high chemoselectivity. The reaction proceeded in the presence of a variety of sensitive functional groups such as esters. The reaction was successfully applied to the total syntheses of biologically active alkaloids.
|
