Development of Rare-Earth Catalyzed Regioselective Functionalization of C-H Bonds

Research Project

Project/Area Number	24750046
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Organic chemistry
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	OYAMADA Juzo 独立行政法人理化学研究所, 環境資源科学研究センター, 特別研究員 (60525393)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	希土類錯体 / C-H結合活性化 / アルキル化 / アニソール / アニリン / N,N-ジアルキルアニリン / オレフィン / 希土類アルキル錯体
Research Abstract	Ortho-selective alkylation of anisoles has been achieved by use of cationic rare-earth alkyl complexes as catalysts. Similarly, 2-methylanisoles underwent ortho-selective benzylic alkylation. These catalysts could also be applied to ortho-selective alkyaltion of N,N-dialkylanilines, alkylation at a N-methyl group of N-methylamines and benzylic alkylation of methylbenzenes.