Research Project
Grant-in-Aid for Young Scientists (B)
Nitric oxide (NO) stands among the most studied molecules in biomedical sciences because of its numerous physiological properties. This reactive radical is a crucial signaling molecule with site-specific and concentration-dependent activities. Bearing in mind that rapid and precise spatiotemporal control of NO delivery are fundamental criteria that a releasing system should meet, we developed NO-releasing platforms based on photoactive porous coordination polymers (PCPs). Organizing molecules with poor reactivity into PCP structures lead to increased photoreactivity and adjustable NO release via light irradiation. We embedded photoactive PCP crystals in a biocompatible polymer matrix and achieved precisely controlled NO delivery at the cellular level via localized two-photon laser activation. We reported a unique example of spatiotemporally controlled release of NO from PCP-hybrids which can be a valuable tool for further investigations of the physiological role of NO.
All 2013 2012 Other
All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Invited: 2 results)
Nature Communications
Volume: 4 Issue: 1 Pages: 2-684
10.1038/ncomms3684
