Mechanism for the signal transduction of CO-gas generated by heme oxygenase together with other proteins in the heme metabolism
| Project/Area Number | 24750169 |
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kurume University |
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Principal Investigator |
HARADA Jiro 久留米大学, 医学部, 講師 (10373094)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed(Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost : ¥3,500,000、Indirect Cost : ¥1,050,000)
Fiscal Year 2014 : ¥650,000 (Direct Cost : ¥500,000、Indirect Cost : ¥150,000)
Fiscal Year 2013 : ¥910,000 (Direct Cost : ¥700,000、Indirect Cost : ¥210,000)
Fiscal Year 2012 : ¥2,990,000 (Direct Cost : ¥2,300,000、Indirect Cost : ¥690,000)
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| Keywords | ヘム酵素 / ヘムオキシゲナーゼ / NMR緩和分散測定 / ヘム代謝 / 国際情報交換 |
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| Outline of Final Research Achievements |
Heme oxygenase catalyzes the degradation of heme. Heme oxygenase has been well characterized and revealed its heme binding mode in detail. In this study, we elucidated dynamics of Heme oxygenase by relaxation dispersion NMR spectroscopy, and detected structural fluctuation of a loop between C- and D-helices located on the surface. Thus far, the loop region has not been paid attention to, because it is located on the protein surface and far from the heme-binding site. Hence, we analyzed and characterized Leu77 and Phe79 which were the fluctuated amino acid residues in the loop.
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Report
(4results)
Research Products
(97results)
