Creation of new molecular release systems based on porous coordination polymer capable and metal nanoparticles capable of remotely deliver biologically active molecules under light irradiation

• Project/Area Number: 24750201
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Inorganic industrial materials
• Research Institution: Kyoto University
• Principal Investigator: REBOUL Julien 京都大学, 物質-細胞統合システム拠点, 助教 (20604747)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 多孔性金属錯体 / 金属ナノ粒子 / 分子放出制御 / 生体活性分子 / 細胞機能評価 / 配位高分子 / 金属錯体 / 多孔体 / 有機無機ハイブリッド / 金ナノ結晶 / プラズモン

Research Abstract

We created new molecular release systems capable of remotely deliver biologically active molecules under light irradiation. To this end, we combined the high storage ability of porous coordination polymers (PCPs), a new class of crystalline materials assembled by organic linkers and inorganic joints at the molecular scale, with the photo-thermal properties of gold nanorods (GNRs) into designed mesoscopic composite materials. These materials consisted in core shell structures composed of a GNR core and an aluminum-based PCP shell. The creation of such mesoscopic structures enabled the implementation of unique motion-induced molecular release, triggered by the highly efficient conversion of optical energy into heat that occurs when the GNRs are irradiated into their plasmon band. Temporal control of the molecular release was demonstrated with anthracene as a guest molecule (priorly immobilized within the pores of the PCP shell) and fluorescent probe by fluorescence spectroscopy.

Research Products

• [Journal Article] Integration of porous coordination polymers and gold nano-rods into core-shell mesoscopic composites towards light-induced molecular release (2013)
  • Author(s): Kira Khaletskaya, Julien Reboul, Mikhail Meilikhov, Masashi Nakahama, Stéphane Diring, Masahiko Tsujimoto, Seiji Isoda, Franklin Kim, Ken-ichiro Kamei, Roland A. Fischer, Susumu Kitagawa and Shuhei Furukawa
  • Journal Title: Journal of the American Chemical Society Volume: 135 Issue: 30 Pages: 10998-11005
  • DOI: 10.1021/ja403108x
  • Peer Reviewed
• [Presentation] Construction of porous coordination polymerarchitectures and composites by a pseudomorphic replacement process (2013)
  • Author(s): Reboul Julien
  • Organizer: 第8回メソ構造物質国際シンポジウムIMMS2013
  • Place of Presentation: 淡路夢舞台国際会議場〈兵庫〉
  • Year and Date: 2013-05-20
• [Presentation] Construction of porous coordination polymer architectures and composites by a pseudomorphic replacement process (2013)
  • Author(s): Julien Reboul
  • Organizer: 63ｒd Japan Society of Coordination Chemistry
  • Place of Presentation: Naha, Japan
• [Presentation] Construction of porous coordination polymer architectures and composites by a pseudomorphic replacement process (2013)
  • Author(s): Julien Reboul
  • Organizer: 8th International Mesostructured Materials Symposium
  • Place of Presentation: Hyogo, Japan
• [Presentation] Mesoscopic architectures of porous frameworks fabricated by a coordination-induced replication of a metal oxide parent phase (2012)
  • Author(s): Reboul Julien
  • Organizer: 錯体化学会第62回討論会
  • Place of Presentation: 富山大学(富山県)
  • Year and Date: 2012-09-23
• [Presentation] Replication as a method for the construction of shaped porous materials (2012)
  • Author(s): Reboul Julien
  • Organizer: 4th International Conference"Smart materials, structures and Systems"(CIMTEC2012)
  • Place of Presentation: Palazzo dei Congressi (Montecatini Terme)
  • Year and Date: 2012-06-12
• [Presentation] Mesoscopic architectures of porous frameworks fabricated by a coordination-induced replication of a metal oxide parent phase
  • Author(s): Reboul Julien
  • Organizer: 錯体化学会第６２回討論会
  • Place of Presentation: 富山大学 五福キャンパス（富山県）
• [Presentation] Replication as a method for the construction of shaped porous materials
  • Author(s): Reboul Julien
  • Organizer: 4th International Conference “Smart materials, structures and Systems”（CIMTEC2012）
  • Place of Presentation: Palazzo dei Congressi (Montecatini Terme, Italy)
• [Book] Metal Organic Framework Materials (2014)
  • Author(s): Julien Reboul, Susumu Kitagawa : John Wiley
  • Publisher: (印刷中)
• [Book] Metal Organic Framework Materials (2014)
  • Author(s): Julien Reboul, Susumu Kitagawa
  • Total Pages: 16
  • Publisher: John Wiley