| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Changes in the mechanical properties of bone are closely related to trabecular bone remodeling. One of a typical example is an increase in fracture risk in osteoporosis, in which structural changes and decreased bone mass result in changes in the stress distribution of trabecular bone. The stress distribution is also affected by bone quality such as nanoscale biological apatite (BAp) crystallite orientation. We proposed a mathematical model of bone remodeling and multiscale stress analysis of trabecular bone using homogenization techniques, in which mechanical properties of the BAp crystallite was considered anisotropic and suggested mechanical adaptation in morphological change of trabeculae. In the present study, we performed bone remodeling simulation and multiscale stress analysis considering BAp crystallite orientation for trabecular bone model and evaluated changes in their fracture risks. The potential of our simulation methods leading to bone quality evaluation was discussed.
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