Evaluation of adsorbed protein film on joint prosthesis material by using electrochemical method
| Project/Area Number |
24760122
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Design engineering/Machine functional elements/Tribology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 人工関節 / 蛋白質 / 境界潤滑膜 / 電気化学測定 / 吸着 / 摩擦 / 摩耗 / 吸着膜 / 低摩擦 / 低摩耗 / 吸着膜構造 |
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| Research Abstract |
Protein adsorbed film on joint prosthesis material affecting tribological property was evaluated by using electrochemical method. Albumin and gamma-globurin contained in natural cynovial fluid was selected for measurement. The combination of ultra-high molecular weight polyethylene (GUR1050) and CoCrMo alloy (ASTMF75) was employed. The potential between CoCrMo alloy and protein solution was measured to understand the behaviour of protein adsorption. Albumin was easily peeled off by shear force, it means the adsorption is weak. Gamma-globulin did not show desorption by shear force. Therefore, the difference of adsorption strength and stability is essence to form protein adsorption film.
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Report
(3 results)
Research Products
(14 results)
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[Presentation]2013
Author(s)
Kazuhiro Nakashima, Yoshinori Sawae, Teruo Murakami, Stefano Mischler
Organizer
5th world tribology congress 2013
Year and Date
2013-09-10
Related Report
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