Numerical analysis of the heating due to inertial cavitation in high-intensity focused ultrasound therapy

• Project/Area Number: 24760143
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Fluid engineering
• Research Institution: Nihon University
• Principal Investigator: OKITA Kohei 日本大学, 生産工学部, 准教授 (20401135)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 超音波 / マイクロバブル / キャビテーション / 数値計算 / 超音波治療 / HIFU / 数値解析

Research Abstract

Modeling and simulation for the enhancement of heating due to inertial cavitation in high-intensity focused ultrasound (HIFU) were studied. Results in in vitro experiments were qualitatively reproduced by the developed numerical method. Impacts of the properties of microbubble for ultrasound frequency and amplitude, the properties of surrounding tissue, initial void fractions and spatial distribution of microbubbles on both heating region and heating efficiency were numerically clarified.

Research Products

• [Journal Article] Microbubble behavior in an ultrasound field for high intensity focused ultrasound therapy enhancement (2013)
  • Author(s): K. Okita, K. Sugiyama, S. Takagi, Y. Matsumoto
  • Journal Title: J. Acoust. Soc. Am. Volume: 134 (2) Pages: 1576-85
  • Peer Reviewed
• [Journal Article] Focus Control Aided by Numerical Simulation in Heterogeneous Media for High-Intensity Focused Ultrasound Treatment (2013)
  • Author(s): R. Narumi, K. Matsuki, S. Mitarai, T. Azuma, K. Okita , A. Sasaki, K. Yoshinaka, S. Takagi, Y. Matsumoto
  • Journal Title: Jpn. J. Appl. Phys Volume: 52
  • NAID: 210000142522
  • Peer Reviewed
• [Journal Article] Mechanical clot damage from cavitation during sonothrombolysis (2013)
  • Author(s): H. Weiss, P. Selvaraj, K. Okita, Y. Matsumoto, A. L. Voie, T. Hoelscher, A.J. Szeri
  • Journal Title: J. Acoust. Soc. Am. Volume: 133(5) Pages: 3159-75
  • Peer Reviewed
• [Presentation] Numerical study on microbubble-enhanced heating for various parameters in EUS-FUS (2013)
  • Author(s): 沖田浩平,前沢峰雪,横田博一,東隆,高木周,松本洋一郎
  • Organizer: 第6回「システム疾患生命科学による先端医療技術開発」シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2013-02-08
• [Presentation] 集束超音波治療におけるシミュレーションを援用した多媒質中の焦点位置制御手法の開発 (2013)
  • Author(s): 鳴見竜太,東隆,沖田浩平,佐々木明,葭仲潔,高木周,松本洋一郎
  • Organizer: 第6回「システム疾患生命科学による先端医療技術開発シンポジウム」
  • Place of Presentation: 東京
  • Year and Date: 2013-02-08
• [Presentation] 大規模計算のためのHIFUシミュレータの開発 (2013)
  • Author(s): 沖田浩平,高木周,松本洋一郎
  • Organizer: 2013年ハイパフォーマンスコンピューティングと計算科学シンポジウム(HPCS2013)
  • Place of Presentation: 東京
• [Presentation] Mechanisms of thrombolysis acceleration by cavitation (2012)
  • Author(s): H. Weiss, P. Selvaraj, G. Ahadi, A. Voie, T. Hoelscher, K. Okita, Y. Matsumoto, A. Szeri
  • Organizer: 65th Annual Meeting of the APS Division of Fluid Dynamics, G16.05
  • Place of Presentation: San Diego, California
• [Presentation] Numerical study on focusing of ultrasound in microbubble-enhanced High-Intensity Focused Ultrasound Therapy (2012)
  • Author(s): K. Okita, S. Takagi, Y. Matsumoto
  • Organizer: European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012)
  • Place of Presentation: Vienna, Austria
• [Presentation] Numerical study on microbubble-enhanced heating for various parameters in EUS-FUS (2012)
  • Author(s): K. Okita , M. Maezawa, S. Takagi, Y. Matsumoto
  • Organizer: 12th International Symposium for Therapeutic Ultrasound
  • Place of Presentation: Heidelberg, Germany
• [Presentation] Development of Focus Control Method Aided by Numerical Simulation In Multi-Structural Media for HIFU Treatment (2012)
  • Author(s): R. Narumi, K. Matsuki, K. Okita, T. Azuma, A. Sasaki, S. Takagi, Y. Matsumoto
  • Organizer: 12th International Symposium for Therapeutic Ultrasound
  • Place of Presentation: Heidelberg, Germany
• [Presentation] Cavitation micro-bubble behavior in ultrasound field for HIFU therapy enhancement (2012)
  • Author(s): Y. Matsumoto, K. Okita, S. Takagi
  • Organizer: 3aPA313, ACOUSTICS 2012 HONG KONG
  • Place of Presentation: Hong Kong
• [Presentation] Cavitation micro-bubble behavior in ultrasound field for HIFU therapy enhancement (2012)
  • Author(s): Y. Matsumoto, K. Okita, S. Takagi
  • Organizer: ACOUSTICS 2012
  • Place of Presentation: Hong Kong
• [Presentation] Numerical Study on Focusing of Ultrasound in Microbubble-enhanced High-Intensity Focused Ultrasound Therapy (2012)
  • Author(s): K. Okita, S. Takagi, Y. Matsumoto
  • Organizer: European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012)
  • Place of Presentation: Vienna, Austria
• [Presentation] Numerical study on microbubble-enhanced heating for variousparameters in EUS-FUS
  • Author(s): 沖田浩平，前沢峰雪，横田博一，東隆，高木周，松本洋一郎
  • Organizer: 第6回「システム疾患生命科学による先端医療技術開発」シンポジウム
  • Place of Presentation: 東京
• [Remarks]
  • URL: http://www.me.cit.nihon-u.ac.jp/lab/okita/