Development of a medical imaging system for better diagnoses of breast cancers

• Project/Area Number: 24760314
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Measurement engineering
• Research Institution: National Defense Medical College
• Principal Investigator: OKAWA Shinpei 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教 (20432049)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 信号処理 / 逆問題 / 医用工学 / 画像再構成 / 光生体計測 / 計測工学 / 応用物理学 / 生体計測

Outline of Final Research Achievements

It was attempted to construct a medical imaging system to reconstruct the optical properties of the biological tissues with high spatial resolution by use of the theory of light propagation in the biological medium for better diagnoses of breast cancers. The influences of the calculation method of the light propagation in the biological medium, such as Monte Carlo method and the photon diffusion equation, on the image reconstruction were investigated. Moreover, the regularization methods to improve the spatial resolution of the reconstructed image were proposed. The effects of the regularization methods were validated with actual measurement systems employing light and the phantoms mimicking the optical properties of biological medium.

Research Products

• [Journal Article] Influence of the light propagation models on a linearized photoacoustic image reconstruction of the light absorption coefficient (2015)
  • Author(s): Okawa, S., Hirasawa, T., Kushibiki, T. and Ishihara, M.
  • Journal Title: Proc SPIE Volume: 9323 Pages: 93231X-93231X
  • DOI: 10.1117/12.2080761
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Image reconstruction of the absorption coefficients with l1-norm minimization from photoacoustic measurements (2014)
  • Author(s): Okawa, S., Hirasawa, T., Kushibiki, T. and Ishihara, M.
  • Journal Title: Quantitative Imaging in Medicine and Surgery Volume: 5(1) Pages: 78-85
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reconstruction of localized fluorescent target from multi-view continuous-wave surface images of small animal with lp sparsity regularization (2014)
  • Author(s): Okawa, S., Ikehara, T., Oda, I. and Yamada, Y.
  • Journal Title: Biomedical Optics Express Volume: 5(6) Issue: 6 Pages: 1839-1860
  • DOI: 10.1364/boe.5.001839
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 光音響計測による生体内光学特性値分布の定量的イメージング (2014)
  • Author(s): 大川晋平，平沢 壮，櫛引俊宏，石原美弥
  • Journal Title: 日本レーザー医学会誌 Volume: 35(2) Pages: 140-150
  • NAID: 130005104725
  • Peer Reviewed / Open Access
• [Journal Article] Numerical evaluation of linearized image reconstruction based on finite element method for biomedical photoacoustic imaging (2013)
  • Author(s): Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
  • Journal Title: Optical Review Volume: 20(5) Issue: 5 Pages: 442-451
  • DOI: 10.1007/s10043-013-0076-4
  • NAID: 10031199896
  • Peer Reviewed
• [Journal Article] Phantom and mouse experiments of time-domain fluorescence tomography using total light approach (2013)
  • Author(s): S. Okawa, A. Yano, K. Uchida, Y. Mitsui, M. Yoshida, M. Takekoshi, A. Marjono, F. Gao, Y. Hoshi, I. Kida, K. Masamoto, and Y. Yamada
  • Journal Title: Biomedical Optics Express Volume: Vol.4 Issue: 4 Pages: 635-651
  • DOI: 10.1364/boe.4.000635
  • Peer Reviewed
• [Presentation] 小動物を対象としたlpスパース正則化による蛍光トモグラフィー画像再構成 (2014)
  • Author(s): 大川晋平，池原辰弥，小田一郎，山田幸生
  • Organizer: 第63回理論応用力学講演会
  • Place of Presentation: 東京工業大学，東京
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] Fluorescence diffuse optical tomography with a regularization minimizing entropy of fluorophore distribution (2014)
  • Author(s): Okawa, S.
  • Organizer: SICE Annual Conference 2014
  • Place of Presentation: Hokkaido University, Sapporo, Japan
  • Year and Date: 2014-09-09 – 2014-09-12
• [Presentation] Reconstruction of the optical absorption coefficient from photoacoustic signals measured by scanning coaxial probe with regularization methods (2014)
  • Author(s): Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
  • Organizer: SPIE Photonics West, Biomedical optics BIOS 2014
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] Comparison of regularization methods for photoacoustic image reconstruction (2013)
  • Author(s): Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
  • Organizer: Conference on Laser Surgery and Medicine 2014
  • Place of Presentation: Yokohama, Kanagawa, Japan
• [Presentation] 光音響技術による分子イメージングと光伝播を考慮した定量的画像再構成 (2013)
  • Author(s): 大川 晋平，平沢 壮，櫛引俊宏，石原美弥
  • Organizer: 第36 回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] A Sparse Reconstruction with Regularization Minimizing Entropy for Magnetoencephalography (2013)
  • Author(s): Shinpei Okawa, Takaaki Nara
  • Organizer: SICE Annaul Conference 2014
  • Place of Presentation: Nagoya, Aichi, Japan
• [Presentation] 層構造を持つヒト皮膚内光学特性値分布の再構成 (2013)
  • Author(s): 小菅智也，大川晋平，正本和人，山田幸生
  • Organizer: 日本機械学会第25回バイオエンジニアリング講演会
  • Place of Presentation: つくば市
• [Presentation] Reconstruction of the optical properties of inhomogeneous medium from photoacoustic signal with lp sparsity regularization (2013)
  • Author(s): S. Okawa, T. Hirasawa, T. Kushibiki, M. Ishihara
  • Organizer: SPIE Photonics West BiOS
  • Place of Presentation: San Francisco
• [Presentation] Comparison of Regularization Methods for Photoacoustic Image Reconstruction (2013)
  • Author(s): S. Okawa, T. Hirasawa, T. Kushibiki, M. Ishihara
  • Organizer: Conference on Laser Surgery and Medicine 2013
  • Place of Presentation: Yokohama