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Development of a medical imaging system for better diagnoses of breast cancers

Research Project

Project/Area Number 24760314
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Measurement engineering
Research InstitutionNational Defense Medical College

Principal Investigator

OKAWA Shinpei  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教 (20432049)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords信号処理 / 逆問題 / 医用工学 / 画像再構成 / 光生体計測 / 計測工学 / 応用物理学 / 生体計測
Outline of Final Research Achievements

It was attempted to construct a medical imaging system to reconstruct the optical properties of the biological tissues with high spatial resolution by use of the theory of light propagation in the biological medium for better diagnoses of breast cancers. The influences of the calculation method of the light propagation in the biological medium, such as Monte Carlo method and the photon diffusion equation, on the image reconstruction were investigated. Moreover, the regularization methods to improve the spatial resolution of the reconstructed image were proposed. The effects of the regularization methods were validated with actual measurement systems employing light and the phantoms mimicking the optical properties of biological medium.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (9 results)

  • [Journal Article] Influence of the light propagation models on a linearized photoacoustic image reconstruction of the light absorption coefficient2015

    • Author(s)
      Okawa, S., Hirasawa, T., Kushibiki, T. and Ishihara, M.
    • Journal Title

      Proc SPIE

      Volume: 9323 Pages: 93231X-93231X

    • DOI

      10.1117/12.2080761

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Image reconstruction of the absorption coefficients with l1-norm minimization from photoacoustic measurements2014

    • Author(s)
      Okawa, S., Hirasawa, T., Kushibiki, T. and Ishihara, M.
    • Journal Title

      Quantitative Imaging in Medicine and Surgery

      Volume: 5(1) Pages: 78-85

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reconstruction of localized fluorescent target from multi-view continuous-wave surface images of small animal with lp sparsity regularization2014

    • Author(s)
      Okawa, S., Ikehara, T., Oda, I. and Yamada, Y.
    • Journal Title

      Biomedical Optics Express

      Volume: 5(6) Issue: 6 Pages: 1839-1860

    • DOI

      10.1364/boe.5.001839

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 光音響計測による生体内光学特性値分布の定量的イメージング2014

    • Author(s)
      大川晋平,平沢 壮,櫛引俊宏,石原美弥
    • Journal Title

      日本レーザー医学会誌

      Volume: 35(2) Pages: 140-150

    • NAID

      130005104725

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Numerical evaluation of linearized image reconstruction based on finite element method for biomedical photoacoustic imaging2013

    • Author(s)
      Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
    • Journal Title

      Optical Review

      Volume: 20(5) Issue: 5 Pages: 442-451

    • DOI

      10.1007/s10043-013-0076-4

    • NAID

      10031199896

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phantom and mouse experiments of time-domain fluorescence tomography using total light approach2013

    • Author(s)
      S. Okawa, A. Yano, K. Uchida, Y. Mitsui, M. Yoshida, M. Takekoshi, A. Marjono, F. Gao, Y. Hoshi, I. Kida, K. Masamoto, and Y. Yamada
    • Journal Title

      Biomedical Optics Express

      Volume: Vol.4 Issue: 4 Pages: 635-651

    • DOI

      10.1364/boe.4.000635

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 小動物を対象としたlpスパース正則化による蛍光トモグラフィー画像再構成2014

    • Author(s)
      大川晋平,池原辰弥,小田一郎,山田幸生
    • Organizer
      第63回理論応用力学講演会
    • Place of Presentation
      東京工業大学,東京
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fluorescence diffuse optical tomography with a regularization minimizing entropy of fluorophore distribution2014

    • Author(s)
      Okawa, S.
    • Organizer
      SICE Annual Conference 2014
    • Place of Presentation
      Hokkaido University, Sapporo, Japan
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reconstruction of the optical absorption coefficient from photoacoustic signals measured by scanning coaxial probe with regularization methods2014

    • Author(s)
      Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
    • Organizer
      SPIE Photonics West, Biomedical optics BIOS 2014
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Comparison of regularization methods for photoacoustic image reconstruction2013

    • Author(s)
      Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
    • Organizer
      Conference on Laser Surgery and Medicine 2014
    • Place of Presentation
      Yokohama, Kanagawa, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 光音響技術による分子イメージングと光伝播を考慮した定量的画像再構成2013

    • Author(s)
      大川 晋平,平沢 壮,櫛引俊宏,石原美弥
    • Organizer
      第36 回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] A Sparse Reconstruction with Regularization Minimizing Entropy for Magnetoencephalography2013

    • Author(s)
      Shinpei Okawa, Takaaki Nara
    • Organizer
      SICE Annaul Conference 2014
    • Place of Presentation
      Nagoya, Aichi, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 層構造を持つヒト皮膚内光学特性値分布の再構成2013

    • Author(s)
      小菅智也,大川晋平,正本和人,山田幸生
    • Organizer
      日本機械学会第25回バイオエンジニアリング講演会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Research-status Report
  • [Presentation] Reconstruction of the optical properties of inhomogeneous medium from photoacoustic signal with lp sparsity regularization2013

    • Author(s)
      S. Okawa, T. Hirasawa, T. Kushibiki, M. Ishihara
    • Organizer
      SPIE Photonics West BiOS
    • Place of Presentation
      San Francisco
    • Related Report
      2012 Research-status Report
  • [Presentation] Comparison of Regularization Methods for Photoacoustic Image Reconstruction2013

    • Author(s)
      S. Okawa, T. Hirasawa, T. Kushibiki, M. Ishihara
    • Organizer
      Conference on Laser Surgery and Medicine 2013
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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