| Project/Area Number |
24760549
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Inorganic materials/Physical properties
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
SHIROSAKI Yuki 九州工業大学, 若手研究者フロンティア研究アカデミー, 准教授 (40533956)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 有機－無機複合体 / カプセル / 薬物徐放 / キトサン / ケイ酸 / ミクロ粒子 / 有機-無機複合体 |
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| Outline of Final Research Achievements |
Chitosan is a polycation and can form the polymerized membranes by the reaction with polyanions. We prepared the chitosan-silicate hybrid membranes via the sol-gel process. Their wettability, mechanical properties, and degradability were controllable by the density of cross-linking between the amino groups of the chitosan chains and the epoxy groups of GPTMS. Moreover, the hybrid membranes had excellent cytocompatibility for various cells, such as osteoblastic cells, fibroblast cells, and human gingival cells. In this study, the capsules were prepared from the chitosan-GPTMS hybrids precursor sol for the controllable releasing by the crosslinking of the chitosan matrix. And then, the capsules were modified by hydroxyapatite to improve their mechanical properties. The drug model was injected by micro manipulation methods.
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