Microbes and cells on surface of nanoporous metals

Research Project

Project/Area Number	24760572
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Structural/Functional materials
Research Institution	Kyoto University
Principal Investigator	HAKAMADA Masataka 京都大学, エネルギー科学研究科, 准教授 (30462849)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords	ナノポーラス / 金 / 抗菌性 / ナノ材料 / 多孔質 / 金属 / 抗菌 / 細菌 / ポーラス材料
Research Abstract	Microbes (Escherichia coli and Staphylococcus epidermidis) were cultured on nanoporous gold fabricated by dealloying. For comparison, they were also cultured on flat gold plate with no nanoporous structure. Numbers of both microbes decreased on nanoporous gold more significantly than those on flat gold plate. Observations with scanning electron microscope and scanning probe microscope revealed that Escherichia coli on nanoporous Au had dimple on its center and that Staphylococcus epidermidis on nanoporous gold had fractured cell membrane. These antibacterial properties of nanoporous gold are presumably attributed to the abnormal effect of nanoporous gold on surrounding organic matters.