Elucidation of penetration mechanisms of surface-functionalized gold nanoparticles into lipid bilayer
| Project/Area Number |
24760624
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
NAKAMURA Hideya 大阪府立大学, 工学(系)研究科(研究院), 助教 (00584426)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 金ナノ粒子 / 脂質２重膜 / 相互作用 / 分子動力学計算 / 脂質2重膜 / 国際研究者交流 |
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| Research Abstract |
In this study, molecular dynamics simulations of interaction of alkanethiol-functionalized gold nanoparticles with lipid bilayer (model of a biological cell membrane) were conducted. In particular, effects of surface charge, length of a carbon chain of the alkanethiol, and composition and structure of the lipid bilayer were analyzed. As a result, effects of surface properties of the gold nanoparticles on their adhesion and penetration mechanism into the model cell membrane at molecular level were elucidated. It was also found that more realistic structure of the lipid bilayer highly induces spontaneous permeation of nanoparticles across the whole lipid bilayer.
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Report
(3 results)
Research Products
(23 results)
