| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
During meiosis, crossover formation between homologous chromosomes is essential for proper segregation of homologous chromosomes. In this study, mutation analysis of Zip3 and identification of Zip3-interacting proteins were performed to reveal how Zip3 contributes to meiotic crossover formation. I revealed that 9-1-1 clamp which localizes on DNA double-strand break sites promotes the localization of Zip3 on the chromosomes, then C-terminus of Zip3 recruits the recombination factor, Msh4-Msh5 complex, to the chromosomes.
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