| Project/Area Number |
24770043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Nagoya University |
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Principal Investigator |
KITAYAMA Yoko 名古屋大学, 理学(系)研究科(研究院), 助教 (20444367)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 生物時計 / 概日リズム / シアノバクテリア / 細胞分裂 / DNA複製 / 生物リズム / ゲノム |
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| Outline of Final Research Achievements |
Circadian rhythm is an endogenous oscillations of physiological activities with a period of ~24 h. Many organisms have circadian rhythms and use the rhythms to enhance their fitness in a day/night changes. Cyanobacterium is only prokaryotes that have circadian rhythms. In cyanobacterium Synechococcus elongatus PCC 7942, kaiA, kaiB and kaiC are essential genes for circadian rhythm generation. I analyzed about DnaA, which is known as DNA replication initiation factor in bacteria and is KaiC-association protein. The mutants with inactivated dnaA were viable, however, shortened the period of circadian rhythm in Synechococcus elongatus PCC 7942. It was also found that there was relationship between DnaA and cell division and circadian clock. It is thought that DnaA modifies the circadian rhythm and cell cycle by interacting with KaiC.
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