| Project/Area Number |
24770058
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
HORIGUCHI Ryo 浜松医科大学, 医学部, 特任研究員 (70452969)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 性転換 / 性的可塑性 / 性決定 / 性分化 / 精巣 / 卵巣 / 魚類 / ミツボシキュウセン / 生殖腺 |
|---|
| Research Abstract |
Sex change in fishes provides a good model for studying sex determination, differentiation and sexual plasticity in vertebrates. In the present study, we examined cellular and molecular process of sex change in the protogynous wrasse focusing on gsdf in order to understand the mechanism of sex change. Pulse chase analysis during sex change from ovary to testis shows that gonial germ cells in the ovary are the origin of sperm. The expression of gsdf was observed in the supporting cells surrounding gonial germ cells, suggesting that gsdf may be involved in the proliferation and masculinization of gonial germ cells in the early process of the sex change.
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