| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Free D-amino acids are widely distributed in living organisms, from bacteria to mammals, and play a key role in specific physiological functions. In invertebrates, D-Ser, D-Asp, D-Ala and D-Arg have been found in various phyla species, and play important physiological roles. In contrast to the wide distribution of D-amino acids, amino acid racemase genes have been identified in few invertebrate species. We searched the nucleotide, EST, and SRA databases, and found 11 serine racemase homologous genes from eight invertebrate phyla species. The cloned genes were identified based on their maximum activity as serine racemase (SerR) and aspartate racemase (AspR). Our results revealed that SerR and AspR are more widely distributed among invertebrates than previously thought.
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