molecular mechanism underlying intracellular heme transport

Research Project

Project/Area Number	24770121
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Functional biochemistry
Research Institution	The University of Tokyo
Principal Investigator	UETA Ryo 東京大学, 医科学研究所, 助教 (10445025)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	ヘム / 鉄 / ミトコンドリア / 出芽酵母
Research Abstract	Using S. cerevisiae, we performed the screening for mutants that are defective in intracellular heme trafficking, and isolated one mutant carrying mutation in a transcriptional regulator. In this mutant, the expression of many genes that are involved in respiration and metabolic pathways processed in mitochondria, suggesting that this transcriptional regulator controls not only heme trafficking, but also mitochondria-related metabolism.