Identification and functional analysis of mTOR downstream molecules using phospho-proteomic technology
Project/Area Number |
24770129
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Functional biochemistry
|
Research Institution | Kyushu University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | mTOR / シグナル伝達 / CCL2 / 血管新生 / 腫瘍随伴マクロファージ |
Research Abstract |
Rapamycin, mTORC1 inhibitor, has drug efficacy of anti-cancer. However, effectors of mTORC1 kinase are not fully understood. To explore the effecetors of mTORC1, we carried out phosphoproteomics analysis and newly identified 30 effectors from the total 20000 phosphopeptides. Next, we analyzed FOXK1 as a transcription factor activated by mTORC1, and identified mTORC1-FOXK1-CCL2 signaling pathway.
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Report
(3 results)
Research Products
(18 results)