| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Mitochondria are dynamic organelles, and their fusion and fission regulate various cellular events. We examined the physiological role of mitochondrial fission in muscle tissue. We found that nucleoid morphology/dynamic are regulated by balanced fusion and fission in the term of this project. In healthy cells, mitochondrial fission often occurred adjacent to nucleoids. In Drp1-deficient cells, nucleoids were highly enlarged by their clustering within hyperfused mitochondria. Thus, mitochondrial dynamics by fission and fusion play a critical role in controlling mitochondrial nucleoid structures, contributing to cristae reformation and the proapoptotic status of mitochondria. Further analysis showed that mitochondrial fission maintains functional mitochondria in muscle tissue.
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