Non-equilibrium statistical mechanics for fluctuations in cells
| Project/Area Number |
24770143
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biophysics
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
HAYASHI Kumiko 東北大学, 工学(系)研究科(研究院), 助教 (00585979)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 1分子計測・操作 / モータータンパク質 / 非平衡統計力学 / 揺動散逸定理 / 揺らぎの定理 / キネシン / ダイニン / 重心揺らぎ / 蛍光観察 / 生体モーター |
|---|
| Research Abstract |
We measured the motion of mitochondria in PC12 cells by using fluorescent observation. A mitochondrion is transported by motor proteins such as kinesin and dynein along microtubules. We investigated the fluctuation-dissipation theorem for this non-equilibrium phenomenon. Comparing motion of Brownian beads incorporated into the cells by electroporation method, we experimentally found that the fluctuation-dissipation theorem was not valid for the motion of a mitochondrion.
|
Report
(3 results)
Research Products
(16 results)
