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analyses of splicing-dependent stress response mechanism

Research Project

Project/Area Number 24770166
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Molecular biology
Research InstitutionKyoto University

Principal Investigator

NINOMIYA Kensuke  京都大学, 医学(系)研究科(研究院), 助教 (00437279)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords遺伝子発現制御 / ストレス応答 / スプライシング / RNA
Research Abstract

We have found a novel mechanism of splicing-dependent regulation of gene expression, attributing to certain stress recovery function of cells. Thus, we analyzed its molecular mechanism and found some candidates for trans-acting proteins required for this splicing-dependent regulation. In addition, we searched for other genes regulated by this novel mechanism and obtained a number of candidate genes.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 Other

All Presentation (2 results) Remarks (1 results)

  • [Presentation] 変異ジストロフィン遺伝子のエキソンスキップによる筋ジストロフィー治療法開発の試み2014

    • Author(s)
      二宮賢介, 佐古有季哉, 萩原正敏
    • Organizer
      第119回日本解剖学会総会全国学術集会
    • Place of Presentation
      栃木県下野市
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 変異ジストロフィン遺伝子のエキソンスキップによる筋ジストロフィー治療法開発の試み

    • Author(s)
      二宮賢介 佐古有季哉 萩原正敏
    • Organizer
      第119回日本解剖学会総会全国学術集会
    • Place of Presentation
      栃木県下野市
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.anat1dadb.med.kyoto-u.ac.jp/Anat1DADB/TOP.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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