analyses of splicing-dependent stress response mechanism

Research Project

Project/Area Number	24770166
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Molecular biology
Research Institution	Kyoto University
Principal Investigator	NINOMIYA Kensuke 京都大学, 医学(系)研究科(研究院), 助教 (00437279)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	遺伝子発現制御 / ストレス応答 / スプライシング / RNA
Research Abstract	We have found a novel mechanism of splicing-dependent regulation of gene expression, attributing to certain stress recovery function of cells. Thus, we analyzed its molecular mechanism and found some candidates for trans-acting proteins required for this splicing-dependent regulation. In addition, we searched for other genes regulated by this novel mechanism and obtained a number of candidate genes.