| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Research Abstract |
Equational segregation of sister chromatids is fundamental for inheritance of accurate genetic information. However, the underlying molecular mechanism ensuring equational segregation is unclear. Chromosomal instability (CIN),characterized by a high incidence of unequal segregation, is a hallmark of cancer cells and it has been suggested that CIN promotes initiation and progression of tumorigenesis. However, the molecular mechanism underlying CIN remains elusive. In this study, we found that the molecular pathway that Aurora B promotes accumulation of SGO1 at centromere. Furthermore, we uncovered that the dysfunction of the molecular network regulating centromeric localization of SGO1 can be a major cause of CIN.
|
