Mechanism of virtual nuclear envelope breakdown
| Project/Area Number |
24770187
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 核構造 / 核膜孔複合体 / 核膜 / 分裂酵母 / 核膜孔 / 減数分裂 |
|---|
| Research Abstract |
In fission yeast, a phenomenon functionally equivalent of nuclear envelope breakdown (virtual nuclear envelope breakdown: V-NEBD) occurs in meiosis to increase nuclear envelope permeability with maintenance of nuclear envelope and nuclear pore structure. To understand the function of nuclear pore complex on the V-NEBD, about 30 proteins composing nuclear pore complex were characterized by their localizations and expression levels. These analyses suggested the unique composition of nuclear pore complex in fission yeast. In addition, gene disruption analysis of the nuclear pore complex genes revealed a gene that regulates the timing of V-NEBD.
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Report
(3 results)
Research Products
(29 results)
