| Project/Area Number |
24770188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
AKANUMA Takashi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50450721)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSOKAWA Yoichiroh 奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (20448088)
MERKS Roeland M. H. Centrum Wiskunde & Informatica, Life Sciences, Professor
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 形 / ばらつき / 非対称分裂 / 拡散 / 国際研究者交流 / オランダ / ライブイメージング / 確率 / 数理モデル |
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| Research Abstract |
Cell-to-cell variability is increasingly appreciated as an integral part of biological systems. In this project, we explored how difference in cell shape affects the determination of future cell behavior. In zebrafish embryos, two kinds of V2 interneurons, V2a and V2b are generated from common V2 progenitor cells. It has been suggested that V2 progenitor cells divide along quasi-random directions and there is no cell fate bias at the time of cell division. However we found that varied shapes of V2 progenitor cells are coupled not only to the cell division orientation but also to the binary cell fate determination in a probabilistic manner. We also established an abstract model for shape-dependent stochastic V2 cells' asymmetric division. We analyzed this model by mathematical simulation in silico, and inspected it by manipulating the zebrafish embryos. Our interdisciplinary approach revealed the design principle for the shape-dependent stochastic asymmetric cell division.
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