| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Mitochondria undergo continuous fusion and fission, which maintain dynamic tubular morphology. We have shown that loss-of-function mutations of Cdc48p, a cytosolic AAA chaperone, induce mitochondrial aggregation. Further analyses revealed that mitochondrial fusion seems to be perturbed in Cdc48p mutants. Moreover, we explored partner proteins functioning together with Cdc48p in mitochondrial morphology regulation, and found that deletion of Shp1p induces aberrant mitochondrial morphology. These results suggests that the Cdc48p-Shp1p complex regulates the mitochondrial fusion event.
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