Regulatory mechanisms for spatiotemporal dynamics of condensins I and II
| Project/Area Number |
24770194
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
NISHIDE Kenji 独立行政法人理化学研究所, 平野染色体ダイナミクス研究室, 基礎科学特別研究員 (70585067)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 染色体 / コンデンシン / 受精卵 |
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| Research Abstract |
Most eukaryotes utilize two different condensin complexes (known as condensins I and II) to regulate mitotic chromosome assembly and segregation. Interestingly, however, condensins I and II exhibit different subcellular localization during interphase. In this study, I have addressed the question of how the subcellular localization of the two complexes is established in mammalian fertilized eggs and somatic cells. It was found that nuclear export of condensin I by an exportin is responsible for the localization pattern, which appears to be conserved among proliferative cells in mammals.
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Report
(3 results)
Research Products
(8 results)
