| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Most eukaryotes utilize two different condensin complexes (known as condensins I and II) to regulate mitotic chromosome assembly and segregation. Interestingly, however, condensins I and II exhibit different subcellular localization during interphase. In this study, I have addressed the question of how the subcellular localization of the two complexes is established in mammalian fertilized eggs and somatic cells. It was found that nuclear export of condensin I by an exportin is responsible for the localization pattern, which appears to be conserved among proliferative cells in mammals.
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