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Elucidation of the regulating mechanism of glycolipid synthesis by intracellular energy sensor AMPK

Research Project

Project/Area Number 24770198
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cell biology
Research InstitutionKyushu University (2013)
The Institute of Physical and Chemical Research (2012)

Principal Investigator

ISHIBASHI Yohei  九州大学, (連合)農学研究科(研究院), 研究員 (90572868)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsスフィンゴ糖脂質 / グルコシルセラミド / AMPK / 糖ヌクレオチド / エネルギー代謝 / 酵素 / 脂質 / セラミド / 脂質代謝 / リソソーム病
Research Abstract

The amount of cellular glucosylceramide (GlcCer) needs to be regulated in an appropriate level because the abnormal accumulation of GlcCer causes several diseases such as Gaucher's disease and Parkinson's disease. However, insights into how cells regulate GlcCer level are yet to be clarified. AMP-activated protein kinase (AMPK), which is a crucial cellular energy sensor, regulates glucose and lipid metabolism to maintain ATP level. In this study, we investigated whether AMPK affect GlcCer metabolism, and found that GlcCer synthesis was negatively regulated by AMPK-dependent mechanism. Our findings suggest that reduction of GlcCer by AMPK activation may become a new treatment option for diseases caused by the accumulation of GlcCer.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results) Book (2 results)

  • [Journal Article] New insights on glucosylated lipids: Metabolism and functions2013

    • Author(s)
      Ishibashi Y, Kohyama-Koganeya A, Hirabayashi Y
    • Journal Title

      Biochim Biophys Acta

      Volume: 1831 (9) Issue: 9 Pages: 1475-1485

    • DOI

      10.1016/j.bbalip.2013.06.001

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] New insights on glucosylated lipids: metabolism and functions2013

    • Author(s)
      Ishibashi Y, Kohyama-Koganeya A, Hirabayashi Y
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 未定

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preparation and characterization of endoglycoceramdiase I, applicable to the comprehensive analysis of glycosphingolipids, using a rhodococcal expression system.2012

    • Author(s)
      Ishibashi Y, et al.
    • Journal Title

      Journal Lipid Research

      Volume: 53 Issue: 10 Pages: 2242-2251

    • DOI

      10.1194/jlr.d028951

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 細胞内エネルギーセンサーAMPKによるグルコシルセラミド合成量制御機構2014

    • Author(s)
      石橋洋平、平林義雄
    • Organizer
      第56回日本脂質生化学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞内エネルギーセンサーAMPKによるグルコシルセラミド合成量制御機構2014

    • Author(s)
      石橋 洋平、平林 義雄
    • Organizer
      第56回 日本脂質生化学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] AMP-ACTIVATED PROTEIN KINASE SUPPRESSES THE BIOSYNTHESIS OF GLUCOSYLCERAMIDE BY REDUCING INTRACELLULAR UDP-GLUCOSE2013

    • Author(s)
      Yohei Ishibashi, Yoshio Hirabayashi
    • Organizer
      Poster presentation at ISN satellite symposium
    • Place of Presentation
      Cancun, Mexico
    • Related Report
      2013 Final Research Report
  • [Presentation] AMP-ACTIVATED PROTEIN KINASE SUPPRESSES THE BIOSYNTHESIS OF GLUCOSYLCERAMIDE BY REDUCING INTRACELLULAR UDP-GLUCOSE2013

    • Author(s)
      Ishibashi Y, Hirabayashi Y
    • Organizer
      ISN satellite symposium
    • Place of Presentation
      Mexico
    • Related Report
      2012 Research-status Report
  • [Presentation] AMP-activated protein kinase negatively regulates Glucosylceramide synthesis2012

    • Author(s)
      Yohei Ishibashi, Yoshio Hirabayashi
    • Organizer
      Oral presentation at the International Conference on the Bioscience of Lipids and Canadian Lipoprotein Conference (Frontiers in Lipid Biology)
    • Place of Presentation
      Banff, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞内エネルギーセンサーAMPKはグルコシルセラミド合成を抑制する2012

    • Author(s)
      石橋洋平、平林義雄
    • Organizer
      第54回日本脂質生化学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] AMP-activated protein kinase negatively regulates Glucosylceramide synthesis2012

    • Author(s)
      Ishibashi Y, Hirabayashi Y
    • Organizer
      International Conference on the Bioscience of Lipids and Canadian Lipoprotein Conference (Frontiers in Lipid Biology)
    • Place of Presentation
      Canada
    • Related Report
      2012 Research-status Report
  • [Book] DP-glucose : ceramide glucosyltransferase (UGCG)2012

    • Author(s)
      Yohei Ishibashi, Yoshio Hirabayashi
    • Publisher
      Handbook of Glycosyltransferases and Related Genes
    • Related Report
      2013 Final Research Report
  • [Book] Handbook of Glycosyltransferases and Related Genes. The chapter "UDP-glucose:ceramide glucosyltransferase (UGCG)"2012

    • Author(s)
      Ishibashi Y, Hirabayashi Y
    • Total Pages
      16
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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