| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Amphibian wound healing, in which blastema cells that express Prrx1 emerge as dedifferentiated cells, leads to a perfect restoration of tissue architecture and function. In this study, I found that mouse embryos at e13.5-e15.5 had a capacity to regenerate dermis after wounding, but wound healing in embryos at e16.5-e18.5 resulted in scar formation, as well as neonates and adults. The regenerating dermis (wounds at e13.5-e15.5) express Prrx1, but the incomplete healing dermis (wounds at e16.5-17.5, neonates and adults) doesn't. In addition, there is a little macrophages in the regenerating dermis, but a lot of macrophages in the incomplete healing dermis.
|
